Valuation: Silence Therapeutics plc

Market Cap 348M 467M 408M 376M 660M 44.49B 671M 4.5B 1.77B 21.92B 1.75B 1.71B 75.35B P/E 2026 *
-16.5x
P/E 2027 * -14.7x
Enterprise Value 201M 270M 236M 218M 382M 25.75B 388M 2.6B 1.02B 12.69B 1.01B 992M 43.61B EV / Sales 2026 *
80.6x
EV / Sales 2027 * 28.5x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 30/11/2025
Director of Finance/CFO 54 31/01/2022
Chief Tech/Sci/R&D Officer - 31/12/2020
Director TitleAgeSince
Director/Board Member 63 20/06/2018
Chairman 72 31/12/2003
Director/Board Member 65 04/05/2025
Change 5-day change 1-year change 3-year change Capi.($)
+8.84%-.--% - - 466M
+0.58%+2.06%+2.92%+10.86% 50.44B
-1.91%-1.58%+385.68%+587.19% 40.63B
-0.69%+0.77%+25.39%-5.41% 34.88B
-1.51%-3.67%+17.64%+54.83% 33.67B
+1.21%-0.79%+4.46%+35.18% 26.29B
-2.19%+0.06% - - 17.11B
-0.05%-5.47%+62.74%+120.93% 15.29B
-8.01%-29.18%+39.00%+41.00% 10.62B
+0.23%-0.58%+13.76%+21.11% 13.74B
Average -0.33%-2.12%+68.95%+108.21% 26.96B
Weighted average by Cap. -0.82%-0.03%+84.13%+131.07%

Financials

2026 *2027 *
Net sales 2.5M 3.35M 2.93M 2.7M 4.74M 319M 4.81M 32.28M 12.68M 157M 12.57M 12.3M 541M 3.44M 4.62M 4.04M 3.73M 6.53M 440M 6.64M 44.51M 17.48M 217M 17.34M 16.96M 746M
Net income -50.34M -67.56M -59.09M -54.5M -95.52M -6.44B -97.13M -651M -256M -3.17B -254M -248M -10.91B -84.67M -114M -99.38M -91.67M -161M -10.84B -163M -1.1B -430M -5.34B -427M -417M -18.35B
Net Debt -146M -197M -172M -159M -278M -18.74B -283M -1.89B -744M -9.23B -738M -722M -31.74B -249M -335M -293M -270M -473M -31.92B -481M -3.23B -1.27B -15.73B -1.26B -1.23B -54.07B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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