Valuation: Ionis Pharmaceuticals, Inc.

Market Cap 7.4B 6.49B 6.13B 5.59B 10.46B 709B 10.53B 73.34B 28.41B 362B 27.77B 27.17B 1,164B P/E 2026 *
-12.4x
P/E 2027 * -22.8x
Enterprise Value 7.29B 6.4B 6.04B 5.51B 10.31B 699B 10.38B 72.32B 28.01B 357B 27.38B 26.79B 1,148B EV / Sales 2026 *
7.93x
EV / Sales 2027 * 5.47x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
1 day+1.57%
1 week+0.14%
Current month-26.28%
1 month-29.77%
3 months-45.18%
6 months-40.06%
Current year-43.75%
1 week 43.01
Extreme 43.0065
46.41
1 month 43.01
Extreme 43.0065
61.77
Current year 43.01
Extreme 43.0065
86.74
1 year 43.01
Extreme 43.0065
86.74
3 years 23.95
Extreme 23.95
86.74
5 years 23.95
Extreme 23.95
86.74
10 years 23.95
Extreme 23.95
86.74
Manager TitleAgeSince
Investor Relations Contact 60 30/06/2012
Chief Executive Officer 64 31/12/2019
Director of Finance/CFO 64 30/04/2000
Director TitleAgeSince
Director/Board Member 64 12/12/2005
Director/Board Member 73 30/04/2002
Director/Board Member 64 24/03/2019
Date Insider Type Main position Quantity % Market Cap. Importance
31/08/26 Others

Chief Technology Officer

110 0.0001%
31/08/26 Others

Executive/Senior Manager

58 0.0000%
31/08/26 Others

Founder

98 0.0001%
Change 5-day change 1-year change 3-year change Capi.($)
+1.57%+0.14%-30.57%-3.85% 7.4B
-0.14%+4.33%+9.00%+31.64% 47.97B
-1.69%+1.48%+50.57%+34.53% 44.5B
+2.56%+7.34%+366.69%+608.26% 43.93B
+0.24%+2.85%+10.67%+94.47% 41.03B
-0.62%-1.11%+4.65%+48.91% 29.85B
-0.28%+1.07%+24.58%+155.58% 17.27B
+3.37%+9.21%+8.32% - 15.34B
-0.46%+1.20%+26.90%+42.21% 15.3B
-2.21%-4.70% - - 14.82B
Average +0.23%+2.13%+52.31%+126.47% 27.74B
Weighted average by Cap. +0.15%+2.79%+76.57%+155.37%

Financials

2026 *2027 *
Net sales 920M 807M 762M 694M 1.3B 88.13B 1.31B 9.12B 3.53B 45.03B 3.45B 3.38B 145B 1.36B 1.2B 1.13B 1.03B 1.93B 131B 1.94B 13.53B 5.24B 66.82B 5.12B 5.01B 215B
Net income -576M -506M -478M -435M -815M -55.23B -821M -5.71B -2.21B -28.22B -2.16B -2.12B -90.68B -330M -290M -274M -249M -467M -31.65B -470M -3.27B -1.27B -16.17B -1.24B -1.21B -51.96B
Net Debt -103M -90.37M -85.35M -77.78M -146M -9.87B -147M -1.02B -396M -5.04B -387M -378M -16.21B 68.31M 59.94M 56.61M 51.59M 96.57M 6.55B 97.26M 677M 262M 3.34B 256M 251M 10.75B
Logo Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
1,480
Date Price Change Volume
25/09/26 US$44.50 +1.57% 6,202,420
24/09/26 US$43.81 -0.27% 6,448,795
23/09/26 US$43.93 -3.98% 3,535,786
22/09/26 US$45.75 +1.89% 4,236,217
21/09/26 US$44.90 +1.04% 4,521,358
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
A
Sell
Consensus
Buy
Mean consensus
OUTPERFORM
Number of Analysts
23
Last Close Price
44.50USD
Average target price
83.64USD
Spread / Average Target
+87.95%

Quarterly revenue - Rate of surprise

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