Valuation: Silence Therapeutics plc

Market Cap 418M 556M 489M 454M 783M 53.82B 797M 5.43B 2.12B 26.25B 2.09B 2.04B 91.08B P/E 2026 *
-19.8x
P/E 2027 * -17.6x
Enterprise Value 272M 362M 318M 295M 510M 35.02B 519M 3.53B 1.38B 17.08B 1.36B 1.33B 59.26B EV / Sales 2026 *
109x
EV / Sales 2027 * 49.1x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day-3.21%
1 week+4.85%
Current month+4.28%
1 month+57.50%
3 months+46.05%
6 months+101.94%
Current year+88.32%
1 week 10.16
Extreme 10.16
11.9
1 month 7.43
Extreme 7.43
11.9
Current year 4.19
Extreme 4.19
11.9
1 year 4.19
Extreme 4.19
11.9
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 30/11/2025
Director of Finance/CFO 54 31/01/2022
Chief Tech/Sci/R&D Officer - 31/12/2020
Director TitleAgeSince
Director/Board Member 63 20/06/2018
Chairman 72 31/12/2003
Director/Board Member 65 04/05/2025
Date Insider Type Main position Quantity % Market Cap.
06/07/26 Sell 865,112 0.6105%
02/01/26 Free

Director

90,000 0.0635%
02/01/26 Free

Chief Technology Officer

300,000 0.2117%
Change 5-day change 1-year change 3-year change Capi.($)
-3.21%+4.85%+86.18%+116.45% 559M
+1.08%-6.74%-2.31%+10.45% 46.06B
+3.13%+5.34%+402.93%+627.64% 38.91B
+2.14%+2.95%+10.83%+67.37% 35.57B
+4.43%-1.51%+6.73%-9.13% 33.13B
+1.23%-1.99%-0.05%+30.76% 26.42B
+0.29%-2.75% - - 16.61B
+14.71%+12.62%+38.50%+145.33% 15.08B
-6.32%-4.59%+4.36%+8.22% 14.08B
+1.82%+0.19%+1.45%-29.80% 12.81B
Average +2.01%-0.59%+60.96%+107.47% 23.92B
Weighted average by Cap. +2.58%-2.43%+75.86%+133.86%

Financials

2026 *2027 *
Net sales 2.5M 3.32M 2.92M 2.71M 4.68M 322M 4.77M 32.46M 12.66M 157M 12.47M 12.2M 544M 3.44M 4.58M 4.03M 3.74M 6.46M 444M 6.57M 44.76M 17.46M 216M 17.2M 16.83M 751M
Net income -50.3M -66.93M -58.87M -54.69M -94.32M -6.48B -96.01M -654M -255M -3.16B -251M -246M -10.97B -84.54M -113M -98.95M -91.92M -159M -10.9B -161M -1.1B -429M -5.31B -422M -413M -18.44B
Net Debt -146M -194M -171M -159M -274M -18.8B -279M -1.9B -740M -9.17B -729M -713M -31.82B -249M -331M -291M -270M -467M -32.06B -475M -3.23B -1.26B -15.64B -1.24B -1.22B -54.25B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
23/07/26 US$11.45 -3.21% 479,696
22/07/26 US$11.83 +9.03% 847,510
21/07/26 US$10.85 +3.43% 162,992
20/07/26 US$10.49 -0.10% 360,152
17/07/26 US$10.50 -3.85% 277,230
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
11.83USD
Average target price
29.17USD
Spread / Average Target
+146.55%

Quarterly revenue - Rate of surprise