Valuation: Silence Therapeutics plc

Market Cap 369M 495M 434M 401M 696M 47.71B 707M 4.79B 1.88B 23.34B 1.86B 1.82B 80.42B P/E 2026 *
-17.6x
P/E 2027 * -15.6x
Enterprise Value 223M 299M 262M 242M 421M 28.86B 428M 2.9B 1.14B 14.12B 1.12B 1.1B 48.65B EV / Sales 2026 *
89.3x
EV / Sales 2027 * 34.9x
Free-Float
69.36%
Yield 2026 *
-
Yield 2027 * -
1 day+0.29%
1 week+13.78%
Current month-3.73%
1 month+40.37%
3 months+33.29%
6 months+103.27%
Current year+73.85%
1 week 8.91
Extreme 8.91
11.19
1 month 6.93
Extreme 6.93
11.19
Current year 4.19
Extreme 4.19
11.19
1 year 4.19
Extreme 4.19
11.19
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 30/11/2025
Director of Finance/CFO 54 31/01/2022
Chief Tech/Sci/R&D Officer - 31/12/2020
Director TitleAgeSince
Director/Board Member 63 20/06/2018
Chairman 72 31/12/2003
Director/Board Member 65 04/05/2025
Date Insider Type Main position Quantity % Market Cap.
06/07/26 Sell 865,112 0.6105%
02/01/26 Free

Director

90,000 0.0635%
02/01/26 Free

Chief Technology Officer

300,000 0.2117%
Change 5-day change 1-year change 3-year change Capi.($)
-0.29%+13.78%+71.31%+97.94% 496M
-0.49%-4.01%+0.61%+2.28% 49.18B
-2.93%-0.13%+378.16%+584.97% 39.58B
-0.52%+2.77%+7.01%+61.95% 34.69B
-0.90%-0.97%+29.30%-9.20% 34.42B
-1.82%-1.48%+0.52%+32.02% 27.11B
-3.37%-4.12% - - 16.21B
-1.87%+0.74%+72.92%+116.33% 15.36B
+1.17%+3.10%+15.87%+16.79% 14.05B
-2.27%+0.28%+19.29%-32.68% 13.02B
Average -0.72%+1.08%+66.11%+96.71% 24.41B
Weighted average by Cap. -0.74%-0.56%+78.50%+121.14%

Financials

2026 *2027 *
Net sales 2.5M 3.35M 2.94M 2.71M 4.71M 323M 4.79M 32.45M 12.72M 158M 12.58M 12.31M 545M 3.44M 4.62M 4.05M 3.74M 6.5M 446M 6.6M 44.76M 17.55M 218M 17.35M 16.97M 751M
Net income -50.24M -67.42M -59.09M -54.62M -94.79M -6.5B -96.31M -653M -256M -3.18B -253M -248M -10.96B -84.43M -113M -99.31M -91.8M -159M -10.93B -162M -1.1B -430M -5.35B -425M -416M -18.42B
Net Debt -146M -195M -171M -158M -275M -18.85B -279M -1.89B -742M -9.22B -734M -718M -31.78B -248M -333M -292M -270M -469M -32.16B -476M -3.23B -1.27B -15.73B -1.25B -1.22B -54.21B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
20/07/26 US$10.43 -0.67% 294,775
17/07/26 US$10.50 -3.85% 277,230
16/07/26 US$10.92 +4.50% 567,829
15/07/26 US$10.45 +7.18% 791,970
14/07/26 US$9.750 +4.95% 338,977
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
10.50USD
Average target price
29.17USD
Spread / Average Target
+177.78%

Quarterly revenue - Rate of surprise