Onxeo S.A. announces that the Company has entered into a Clinical Research Agreement with Gustave Roussy to conduct the REVOCAN1 phase 1b/2 study designed to evaluate the effect of AsiDNA™, Onxeo’s first-in-class DDR inhibitor, on the acquired resistance to PARP inhibitor (PARPi) niraparib in its approved indication for 2nd line maintenance treatment of relapsed ovarian cancer. While niraparib significantly delayed cancer progression in both patients with and without a BRCA mutation3, treatment efficacy diminishes overtime as tumors establish new repair pathways and resist to treatment. In preclinical studies, AsiDNA™ has consistently demonstrated its capacity to prevent or abrogate the acquired resistance of the tumors to PARP inhibitors, regardless of tumor mutations. Gustave Roussy and Onxeo have collaborated on REVOCAN multi-center trial design that Gustave Roussy will submit, as study sponsor, to the French health authority (ANSM) and Ethics Committee in the coming weeks, with the aim to start enrolling patients in the first semester of 2020 and obtain preliminary results before year-end.