Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 9.01B 7.82B 7.32B 6.7B 12.62B 857B 12.81B 85.61B 33.6B 429B 33.81B 33.08B 1,427B P/E 2026 *
-15.2x
P/E 2027 * -29.5x
Enterprise Value 8.61B 7.47B 6.99B 6.4B 12.07B 819B 12.25B 81.85B 32.12B 410B 32.32B 31.62B 1,364B EV / Sales 2026 *
9.35x
EV / Sales 2027 * 6.25x
Free-Float
99.09%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 30/06/2012
Chief Executive Officer 64 31/12/2019
Director of Finance/CFO 64 30/04/2000
Director TitleAgeSince
Director/Board Member 64 12/12/2005
Director/Board Member 73 30/04/2002
Director/Board Member 64 24/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 9.01B
+0.93%-1.43%+1.61%+14.93% 48.57B
+0.26%+9.34%+415.26%+533.80% 41.95B
-1.53%-6.11%+26.37%+7.15% 38.85B
+0.69%+0.79%+7.35%+63.05% 37.24B
+2.47%+8.33%+15.16%+48.37% 30.67B
-0.47%+0.01%+34.08%+126.09% 16.41B
+2.31%-0.87% - - 16.1B
+0.29%+1.81%+4.92%+18.60% 13.97B
-1.43%-9.55%-2.90%-36.38% 12.62B
Average +0.48%-0.30%+62.73%+96.95% 28.48B
Weighted average by Cap. +0.47%+0.39%+82.62%+121.09%

Financials

2026 *2027 *
Net sales 921M 799M 748M 685M 1.29B 87.58B 1.31B 8.75B 3.44B 43.86B 3.46B 3.38B 146B 1.4B 1.22B 1.14B 1.04B 1.96B 133B 1.99B 13.32B 5.23B 66.75B 5.26B 5.15B 222B
Net income -590M -512M -479M -439M -827M -56.12B -839M -5.61B -2.2B -28.1B -2.21B -2.17B -93.5B -319M -277M -259M -237M -447M -30.32B -453M -3.03B -1.19B -15.18B -1.2B -1.17B -50.51B
Net Debt -396M -343M -321M -294M -554M -37.62B -563M -3.76B -1.48B -18.84B -1.49B -1.45B -62.69B -241M -209M -196M -179M -337M -22.89B -342M -2.29B -898M -11.46B -904M -884M -38.14B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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