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Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 12.25B 10.68B 9.89B 9.26B 17.37B 1,156B 17.47B 117B 45.48B 569B 45.98B 44.99B 1,975B P/E 2026 *
-20.5x
P/E 2027 * -57.5x
Enterprise Value 12.03B 10.49B 9.71B 9.09B 17.06B 1,135B 17.16B 115B 44.66B 559B 45.16B 44.19B 1,940B EV / Sales 2026 *
13.5x
EV / Sales 2027 * 8.12x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 30/06/2012
Chief Executive Officer 64 31/12/2019
Director of Finance/CFO 64 30/04/2000
Director TitleAgeSince
Director/Board Member 64 12/12/2005
Director/Board Member 73 30/04/2002
Director/Board Member 64 24/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 12.25B
+1.44%+1.71%-10.63%-9.16% 43.13B
+3.31%+5.93%+308.19%+562.02% 34.65B
+2.84%+2.14%+6.87%+34.93% 30.03B
-1.70%-7.54%+8.51%-22.34% 28B
-1.90%-1.56%+11.62%+19.80% 24.45B
-0.14%+5.86% - - 14.34B
+0.68%-1.53%+52.04%+107.47% 13.14B
-0.57%-2.43%+5.18%+4.20% 12.53B
+1.91%-0.12%+1.69%-37.64% 11.18B
Average +0.72%+0.40%+47.93%+82.41% 23.5B
Weighted average by Cap. +0.92%+1.12%+59.44%+106.69%

Financials

2026 *2027 *
Net sales 890M 776M 719M 673M 1.26B 83.97B 1.27B 8.53B 3.3B 41.33B 3.34B 3.27B 144B 1.49B 1.3B 1.21B 1.13B 2.12B 141B 2.13B 14.31B 5.55B 69.37B 5.61B 5.49B 241B
Net income -595M -519M -481M -450M -844M -56.15B -849M -5.7B -2.21B -27.64B -2.23B -2.19B -95.97B -216M -188M -174M -163M -306M -20.37B -308M -2.07B -801M -10.03B -810M -793M -34.81B
Net Debt -219M -191M -177M -166M -311M -20.68B -313M -2.1B -814M -10.18B -823M -805M -35.34B -122M -106M -98.39M -92.1M -173M -11.5B -174M -1.17B -452M -5.66B -457M -448M -19.65B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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