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Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 12.54B 10.96B 10.14B 9.46B 17.76B 1,185B 17.89B 120B 46.87B 583B 47.09B 46.07B 2,024B P/E 2026 *
-21x
P/E 2027 * -58.8x
Enterprise Value 12.32B 10.77B 9.96B 9.3B 17.45B 1,165B 17.58B 118B 46.05B 573B 46.27B 45.26B 1,989B EV / Sales 2026 *
13.8x
EV / Sales 2027 * 8.31x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 30/06/2012
Chief Executive Officer 64 31/12/2019
Director of Finance/CFO 64 30/04/2000
Director TitleAgeSince
Director/Board Member 64 12/12/2005
Director/Board Member 73 30/04/2002
Director/Board Member 64 24/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 12.54B
+1.90%+1.09%-10.67%-5.05% 43.24B
+1.73%+3.59%+318.08%+564.04% 35.25B
+0.61%+1.34%+10.00%+46.20% 30.22B
+0.02%-5.93%+8.45%-21.44% 28.01B
-1.06%-3.71%+9.08%+19.56% 24.08B
-1.23%+2.11% - - 14.16B
-0.99%-2.53%+47.29%+102.88% 13.01B
+1.92%+2.01%+7.49%+13.08% 12.7B
-3.61%-4.73%-3.93%-38.09% 10.78B
Average -0.18%-1.08%+48.22%+85.15% 23.49B
Weighted average by Cap. +0.17%-0.60%+61.72%+111.64%

Financials

2026 *2027 *
Net sales 890M 778M 719M 671M 1.26B 84.1B 1.27B 8.55B 3.33B 41.35B 3.34B 3.27B 144B 1.49B 1.31B 1.21B 1.13B 2.12B 141B 2.13B 14.35B 5.58B 69.4B 5.61B 5.49B 241B
Net income -595M -520M -481M -449M -843M -56.24B -849M -5.72B -2.22B -27.65B -2.23B -2.19B -96.06B -216M -189M -174M -163M -306M -20.4B -308M -2.07B -807M -10.03B -810M -793M -34.84B
Net Debt -219M -191M -177M -165M -310M -20.71B -313M -2.1B -819M -10.18B -823M -805M -35.37B -122M -106M -98.48M -91.91M -173M -11.51B -174M -1.17B -455M -5.66B -457M -448M -19.67B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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