Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 7.4B 6.5B 6.15B 5.58B 10.48B 710B 10.54B 73.57B 28.43B 362B 27.76B 27.16B 1,164B P/E 2026 *
-12.7x
P/E 2027 * -23.4x
Enterprise Value 7.29B 6.41B 6.06B 5.5B 10.33B 700B 10.39B 72.55B 28.03B 357B 27.38B 26.78B 1,148B EV / Sales 2026 *
7.93x
EV / Sales 2027 * 5.47x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 30/06/2012
Chief Executive Officer 64 31/12/2019
Director of Finance/CFO 64 30/04/2000
Director TitleAgeSince
Director/Board Member 64 12/12/2005
Director/Board Member 73 30/04/2002
Director/Board Member 64 24/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 7.4B
+2.64%+7.07%+11.87%+38.40% 47.97B
+0.22%+1.71%+50.91%+34.00% 44.5B
-1.58%+5.65%+359.34%+598.06% 43.93B
+1.70%+4.61%+12.56%+90.97% 41.03B
+0.51%-0.61%+5.18%+46.87% 29.85B
-0.48%+0.59%+23.98%+148.36% 17.27B
+0.08%+9.30%+8.41% - 15.34B
+1.76%+2.98%+29.13%+45.78% 15.3B
+1.97%-2.82% - - 14.82B
Average +0.82%+2.46%+62.67%+143.21% 30B
Weighted average by Cap. +0.76%+2.97%+79.47%+158.52%

Financials

2026 *2027 *
Net sales 920M 809M 764M 694M 1.3B 88.26B 1.31B 9.15B 3.54B 45.01B 3.45B 3.38B 145B 1.36B 1.2B 1.13B 1.03B 1.93B 131B 1.95B 13.58B 5.25B 66.8B 5.12B 5.01B 215B
Net income -576M -507M -479M -435M -817M -55.31B -821M -5.73B -2.22B -28.2B -2.16B -2.12B -90.68B -330M -290M -274M -249M -468M -31.69B -471M -3.28B -1.27B -16.16B -1.24B -1.21B -51.96B
Net Debt -103M -90.58M -85.6M -77.71M -146M -9.88B -147M -1.02B -396M -5.04B -387M -378M -16.21B 68.31M 60.08M 56.77M 51.54M 96.79M 6.56B 97.36M 680M 263M 3.34B 256M 251M 10.75B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Global
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