Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 7.63B 6.73B 6.37B 5.77B 10.83B 732B 10.93B 76.39B 29.44B 374B 28.64B 28.01B 1,203B P/E 2026 *
-12.8x
P/E 2027 * -23.5x
Enterprise Value 7.52B 6.64B 6.28B 5.7B 10.68B 722B 10.79B 75.36B 29.04B 369B 28.25B 27.64B 1,186B EV / Sales 2026 *
8.18x
EV / Sales 2027 * 5.64x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 30/06/2012
Chief Executive Officer 64 31/12/2019
Director of Finance/CFO 64 30/04/2000
Director TitleAgeSince
Director/Board Member 64 12/12/2005
Director/Board Member 73 30/04/2002
Director/Board Member 64 24/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 7.63B
-0.36%+3.67%+10.47%+38.50% 48.85B
-0.73%-0.41%+48.84%+36.72% 44.28B
+1.36%+6.03%+343.85%+638.73% 43.83B
-0.47%-0.76%+9.75%+103.07% 41.53B
+0.34%+0.22%+5.18%+47.36% 30.13B
+1.00%-1.28%+24.23%+156.93% 17.36B
-0.87%-0.74%+22.37%+44.44% 14.99B
-2.94%+6.98%+5.10% - 14.9B
-0.86%-4.00% - - 14.98B
Average +0.07%+0.61%+58.72%+152.25% 30.09B
Weighted average by Cap. +0.00%+1.21%+74.79%+168.48%

Financials

2026 *2027 *
Net sales 920M 811M 768M 696M 1.31B 88.24B 1.32B 9.21B 3.55B 45.06B 3.45B 3.38B 145B 1.36B 1.2B 1.14B 1.03B 1.94B 131B 1.96B 13.67B 5.27B 66.87B 5.12B 5.01B 215B
Net income -576M -509M -481M -436M -818M -55.29B -826M -5.77B -2.22B -28.24B -2.16B -2.12B -90.86B -330M -291M -276M -250M -469M -31.68B -473M -3.31B -1.27B -16.18B -1.24B -1.21B -52.06B
Net Debt -103M -90.89M -85.99M -77.99M -146M -9.88B -148M -1.03B -398M -5.05B -387M -378M -16.24B 68.31M 60.28M 57.04M 51.73M 96.98M 6.55B 97.93M 684M 264M 3.35B 256M 251M 10.77B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Global
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