Valuation: Spyre Therapeutics, Inc.

Market Cap 9.88B 8.95B 8.28B 7.47B 14.08B 931B 14.57B 99.45B 39.43B 497B 37.06B 36.28B 1,579B P/E 2026 *
-32.8x
P/E 2027 * -26.5x
Enterprise Value 8.98B 8.14B 7.52B 6.79B 12.79B 846B 13.25B 90.39B 35.84B 452B 33.69B 32.97B 1,435B EV / Sales 2026 *
-
EV / Sales 2027 * -
Free-Float
93.91%
Yield 2026 *
-
Yield 2027 * -
1 day+1.06%
1 week+0.13%
Current month+7.71%
1 month+29.27%
3 months+2.11%
6 months+36.29%
Current year+217.46%
1 week 100.49
Extreme 100.49
110.64
1 month 76.87
Extreme 76.87
110.64
Current year 28
Extreme 28
110.64
1 year 23.01
Extreme 23.01
110.64
3 years 8.75
Extreme 8.75
110.64
5 years 2.66
Extreme 2.66
181.82
10 years 2.66
Extreme 2.66
300
Manager TitleAgeSince
Chief Executive Officer 36 26/11/2023
Director of Finance/CFO 49 31/08/2023
Chief Tech/Sci/R&D Officer - 26/11/2023
Director TitleAgeSince
Director/Board Member 36 26/11/2023
Director/Board Member 40 21/06/2023
Director/Board Member 36 21/06/2023
Date Insider Type Main position Quantity % Market Cap. Importance
01/10/26 Exercice

General Counsel

86,799 0.0984%
01/10/26 Exercice

Chief Financial Officer

22,500 0.0255%
01/10/26 Sell

Chief Executive Officer

-15,000 0.0170%
Change 5-day change 1-year change 3-year change Capi.($)
+1.06%+0.13%+359.57%+921.61% 9.88B
-2.69%-0.48%+51.67%+69.09% 66.33B
-0.92%+7.67%+14.26%+90.92% 60.62B
0.00%+0.39%+20.52%+98.45% 55.5B
+0.14%+2.35%+13.08%+109.47% 47.58B
-2.21%-2.47%+18.60%+36.89% 43.69B
-2.30%-10.40%+167.61%+776.79% 37.27B
+2.15%+1.42%+15.17%+56.49% 36.57B
-2.32%-2.24%+75.52%+52.70% 32.22B
+2.62%+5.90%-36.55%+406.95% 26.58B
Average -0.45%-0.70%+69.94%+261.94% 42B
Weighted average by Cap. -0.78%-0.51%+44.88%+180.21%

Financials

2026 *2027 *
Net sales - -
Net income -294M -266M -246M -222M -419M -27.72B -434M -2.96B -1.17B -14.81B -1.1B -1.08B -47.01B -400M -363M -336M -303M -571M -37.75B -591M -4.03B -1.6B -20.17B -1.5B -1.47B -64.02B
Net Debt -899M -815M -754M -680M -1.28B -84.81B -1.33B -9.06B -3.59B -45.3B -3.38B -3.3B -144B -844M -765M -708M -639M -1.2B -79.62B -1.25B -8.5B -3.37B -42.53B -3.17B -3.1B -135B
Projected Income Statement - Annual - Spyre Therapeutics, Inc.
Logo Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, specializing in long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. The Company's pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. It is advancing a pipeline of monoclonal antibodies (mAbs) for the treatment of IBD and other immune-mediated diseases. The Company's pipeline includes its SKYLINE Phase II platform trial evaluating SPY001, SPY002, SPY003, and pairwise combinations thereof in subjects with moderately to severely active UC and its SKYWAY basket trial evaluating SPY072 in three rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA). SPY001 is a highly potent, highly selective, and humanized monoclonal immunoglobulin G1 investigational antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD (UC and CD).
Employees
130
Date Price Change Volume
13/11/26 US$104.00 +1.06% 746,235
12/11/26 US$102.91 -3.66% 985,835
11/11/26 US$106.82 +2.24% 894,998
10/11/26 US$104.48 -4.15% 1,003,967
09/11/26 US$109.00 +4.95% 1,393,651
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
MarketScreener Ratings - Spyre Therapeutics, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
18
Last Close Price
104.00USD
Average target price
123.87USD
Spread / Average Target
+19.10%
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