Sirnaomics Ltd. announced the successful completion of cohort 1 in an ongoing Phase I clinical trial of STP122G, targeting Factor XI as a novel form of anticoagulation. Cohort 1 is comprised of eight subjects who completed dosing and were followed over a period of 140 days. Safety data showed there were no dose-limiting toxicities or serious adverse events, so the study will proceed to the next dosing cohort.

The phase I, multicenter, randomized, double-blind, sequential cohort study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose of STP122G when administered subcutaneously to healthy participants. The safety and tolerability will be compared among five different doses of STP122G (25 mg, 50 mg, 100 mg, 200 mg, 400 mg) to select one for future studies. The study plans to recruit 40 total participants.