Valuation: Silence Therapeutics plc

Market Cap 884M 1.18B 1.05B 973M 1.66B 112B 1.68B 11.72B 4.62B 58.65B 4.44B 4.34B 186B P/E 2026 *
-38.6x
P/E 2027 * -31.7x
Enterprise Value 750M 1B 895M 825M 1.41B 94.94B 1.43B 9.94B 3.92B 49.74B 3.76B 3.68B 158B EV / Sales 2026 *
2,281x
EV / Sales 2027 * 932x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 30/11/2025
Director of Finance/CFO 54 31/01/2022
Chief Tech/Sci/R&D Officer - 31/12/2020
Director TitleAgeSince
Director/Board Member 63 20/06/2018
Chairman 72 31/12/2003
Director/Board Member 65 04/05/2025
Change 5-day change 1-year change 3-year change Capi.($)
-4.10%-8.35%+38.48%+66.99% 66.22B
-0.41%+3.27%+10.46%+73.74% 55.2B
+0.74%+4.04%+12.18%+91.76% 52.79B
-0.88%+2.84%+27.95%+51.73% 45.53B
-1.60%+1.91%+21.58%+125.93% 43.94B
-4.16%-0.42%+255.72%+926.75% 41.64B
-1.67%+8.06%+14.17%+56.67% 34B
-8.38%-9.01%+25.65%-1.82% 25.84B
+1.30%+4.94%+38.23%+28.03% 23.51B
Average -2.08%+3.43%+49.38%+157.75% 43.19B
Weighted average by Cap. -1.96%+3.43%+48.06%+160.47%

Financials

2026 *2027 *
Net sales 329K 439K 392K 362K 617K 41.62M 626K 4.36M 1.72M 21.81M 1.65M 1.61M 69.09M 760K 1.02M 907K 837K 1.43M 96.28M 1.45M 10.08M 3.97M 50.44M 3.82M 3.73M 160M
Net income -42.57M -56.9M -50.79M -46.86M -79.87M -5.39B -81.09M -565M -222M -2.82B -214M -209M -8.95B -64.86M -86.69M -77.38M -71.39M -122M -8.21B -124M -860M -339M -4.3B -325M -318M -13.63B
Net Debt -134M -180M -160M -148M -252M -17.01B -256M -1.78B -702M -8.91B -674M -660M -28.24B -176M -235M -210M -193M -330M -22.26B -335M -2.33B -918M -11.66B -882M -863M -36.94B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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MarketScreener Ratings - Silence Therapeutics plc