Valuation: Silence Therapeutics plc

Market Cap 449M 594M 530M 493M 847M 57.46B 851M 5.94B 2.33B 29.29B 2.23B 2.18B 94B P/E 2026 *
-19.3x
P/E 2027 * -15.9x
Enterprise Value 316M 418M 373M 347M 596M 40.41B 598M 4.18B 1.64B 20.6B 1.57B 1.53B 66.11B EV / Sales 2026 *
971x
EV / Sales 2027 * 314x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Chief Executive Officer 72 30/11/2025
Director of Finance/CFO 54 31/01/2022
Chief Tech/Sci/R&D Officer - 31/12/2020
Director TitleAgeSince
Director/Board Member 63 20/06/2018
Chairman 72 31/12/2003
Director/Board Member 65 04/05/2025
Change 5-day change 1-year change 3-year change Capi.($)
-2.59%-5.70%+39.83%+82.45% 70.61B
+3.23%-10.67%+4.87%+55.97% 51.01B
+1.56%+1.17%+5.15%+33.38% 48.1B
+0.39%+0.65%+28.02%+30.24% 42.78B
+0.87%-8.17%+298.53%+645.03% 40.67B
+1.24%-1.01%+5.56%+105.14% 40.3B
-2.13%-1.64%+7.51%+50.31% 30.59B
-0.46%-1.28%+31.47%+19.93% 28.16B
+5.32%+0.06%-7.20%-11.30% 24.36B
Average +0.83%-2.66%+45.97%+112.35% 41.84B
Weighted average by Cap. +0.56%-2.94%+47.30%+116.51%

Financials

2026 *2027 *
Net sales 325K 430K 384K 357K 614K 41.62M 616K 4.3M 1.69M 21.22M 1.62M 1.58M 68.1M 876K 1.16M 1.03M 963K 1.65M 112M 1.66M 11.59M 4.54M 57.17M 4.35M 4.26M 183M
Net income -42.18M -55.82M -49.85M -46.37M -79.64M -5.4B -79.99M -558M -219M -2.75B -210M -205M -8.84B -64.3M -85.09M -75.99M -70.69M -121M -8.23B -122M -851M -333M -4.2B -320M -313M -13.47B
Net Debt -133M -176M -157M -146M -251M -17.05B -252M -1.76B -690M -8.69B -661M -647M -27.89B -174M -230M -206M -191M -329M -22.29B -330M -2.3B -902M -11.36B -865M -846M -36.47B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
-
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Ratings Surperformance© - Silence Therapeutics plc