On September 17, 2018, BioTime, Inc. announced that its Board of Directors appointed Brian M. Culley as its President and Chief Executive Officer effective September 17, 2018. In this capacity, Mr. Culley will serve as the Company’s principal executive officer. Mr. Culley commenced his employment with the company on September 17, 2018. Additionally, effective September 17, 2018, the Board appointed Mr. Culley to the company’s Board, to serve as a director with a term to expire at the company’s 2019 Annual Meeting of Shareholders and until his successor has been duly elected and qualified, or, if sooner, until his death, resignation or removal. Prior to joining BioTime, Mr. Culley served from August 2017 to September 17, 2018 as Interim Chief Executive Officer at Artemis Therapeutics, Inc., a, where he was responsible for the management of the company. Mr. Culley previously served as Chief Executive Officer of Mast Therapeutics, Inc. (“Mast”), from February 2010, and was also a member of its Board of Directors from December 2011, until Mast’s merger with Savara, Inc. in April 2017. Mr. Culley served from January 2007 to February 2010 as Mast’s Chief Business Officer and Senior Vice President, from February 2006 to January 2007 as Mast’s Senior Vice President, Business Development, and from December 2004 to February 2006 as Mast’s Vice President, Business Development. From 2002 until 2004, Mr. Culley was Director of Business Development and Marketing for Immusol, Inc. Effective as of September 17, 2018, Aditya P. Mohanty and Michael D. West, Co-Chief Executive Officers of BioTime, will cease serving in those roles and cease serving as executive officers of the Company. Mr. Mohanty and Dr. West will also cease serving as a director on the company’s Board effective September 17, 2018. Mr. Mohanty’s resignation was not the result of any disagreement with the Company on any matter relating to the company’s operations, policies or practices. Dr. West has also resigned from the board of Asterias Biotherapeutics, Inc. (“Asterias”) and from all other positions he currently holds with the Company or its subsidiaries and affiliates, effective September 17, 2018, except that Dr. West will continue to serve as the CEO and on the board of AgeX Therapeutics, Inc. Mr. Mohanty will continue to serve on the boards of OncoCyte Corporation and Asterias as well as other subsidiaries on behalf of the company and has agreed to resign from those boards at the request of the company. The company thanks Mr. Mohanty and Dr. West for their services.