Valuation: Denali Therapeutics Inc.

Market Cap 3.94B 3.41B 3.18B 2.92B 5.49B 375B 5.58B 37.35B 14.66B 188B 14.8B 14.47B 621B P/E 2026 *
-11.1x
P/E 2027 * -10.8x
Enterprise Value 3.31B 2.87B 2.68B 2.45B 4.62B 315B 4.69B 31.4B 12.32B 158B 12.44B 12.17B 522B EV / Sales 2026 *
49.1x
EV / Sales 2027 * 25.8x
Free-Float
89.44%
Yield 2026 *
-
Yield 2027 * -
1 day+0.40%
1 week+7.86%
Current month+7.86%
1 month-6.97%
3 months+26.55%
6 months+17.79%
Current year+50.39%
1 week 22.63
Extreme 22.6275
25.74
1 month 22.01
Extreme 22.01
27.11
Current year 15.34
Extreme 15.34
27.3
1 year 12.58
Extreme 12.58
27.3
3 years 10.57
Extreme 10.57
33.33
5 years 10.57
Extreme 10.57
56.8
10 years 10.57
Extreme 10.57
93.94
Manager TitleAgeSince
Director of Finance/CFO 52 30/04/2022
Chief Executive Officer 50 31/07/2015
Chief Tech/Sci/R&D Officer 58 05/11/2025
Director TitleAgeSince
Director/Board Member 50 28/02/2015
Director/Board Member 73 31/03/2015
Director/Board Member 68 31/03/2015
Date Insider Type Main position Quantity % Market Cap.
03/06/26 Free

Director

25,634 0.0162%
10/04/26 Other

Chief Technology Officer

204,402 0.1289%
06/01/26 Sell

Founder

17,218 0.0110%
Change 5-day change 1-year change 3-year change Capi.($)
+0.40%+7.86%+77.87%-3.87% 3.94B
+8.49%+20.55%+70.77%+110.32% 68.12B
+1.25%+2.44%+34.27%+70.43% 55.18B
-1.09%+32.96%+19.67%+494.56% 28.63B
+10.83%+18.38%+56.20%+6.03% 23.99B
+2.72%+3.41%-16.11%-7.96% 23.53B
+6.50%+7.56%+44.65%-21.73% 18.45B
+6.20%+11.51%+33.87%+693.38% 16.44B
-3.88%+16.98%+199.30%+359.77% 15.83B
+3.58%+1.96%+43.35%+163.76% 13.4B
Average +3.50%+11.30%+56.38%+186.47% 26.75B
Weighted average by Cap. +4.30%+13.02%+51.09%+165.94%

Financials

2026 *2027 *
Net sales 67.47M 58.36M 54.5M 49.99M 94.03M 6.42B 95.52M 639M 251M 3.22B 253M 248M 10.64B 126M 109M 101M 93.08M 175M 11.95B 178M 1.19B 467M 5.99B 472M 461M 19.81B
Net income -444M -384M -359M -329M -619M -42.24B -628M -4.21B -1.65B -21.17B -1.67B -1.63B -70B -444M -384M -359M -329M -620M -42.3B -629M -4.21B -1.65B -21.2B -1.67B -1.63B -70.1B
Net Debt -628M -543M -507M -465M -875M -59.77B -889M -5.95B -2.34B -29.96B -2.36B -2.31B -99.04B -695M -601M -562M -515M -969M -66.16B -984M -6.59B -2.59B -33.16B -2.61B -2.55B -110B
Logo Denali Therapeutics Inc.
Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.
Employees
507
Date Price Change Volume
07/08/26 US$24.83 +0.40% 1,750,014
06/08/26 US$24.73 +1.27% 3,049,280
05/08/26 US$24.42 +1.03% 1,094,213
04/08/26 US$24.17 +4.41% 993,770
03/08/26 US$23.15 +0.56% 1,476,216
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
20
Last Close Price
24.83USD
Average target price
34.50USD
Spread / Average Target
+38.94%

Quarterly revenue - Rate of surprise

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