Valuation: Denali Therapeutics Inc.

Capitalization 2.93B 2.53B 2.35B 2.19B 4.07B 265B 4.37B 27.05B 10.64B 127B 11B 10.77B 465B P/E ratio 2025 *
-6.34x
P/E ratio 2026 * -6.56x
Enterprise value 2.32B 2B 1.87B 1.74B 3.23B 210B 3.46B 21.43B 8.43B 100B 8.71B 8.53B 368B EV / Sales 2025 *
871x
EV / Sales 2026 * 37.7x
Free-Float
90.34%
Yield 2025 *
-
Yield 2026 * -
More valuation ratios * Estimated data
Dynamic Chart
1 day+2.79%
1 week+10.02%
Current month+13.75%
1 month+8.30%
3 months+15.14%
6 months+32.53%
Current year+13.75%
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1 week 16.96
Extreme 16.96
18.98
1 month 15.34
Extreme 15.34
18.98
Current year 15.34
Extreme 15.34
18.98
1 year 10.57
Extreme 10.57
24.34
3 years 10.57
Extreme 10.57
33.33
5 years 10.57
Extreme 10.57
83.98
10 years 10.57
Extreme 10.57
93.94
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Manager TitleAgeSince
Director of Finance/CFO 52 30/04/2022
Chief Executive Officer 50 31/07/2015
Chief Tech/Sci/R&D Officer - 31/12/2019
Director TitleAgeSince
Director/Board Member 50 28/02/2015
Chairman 66 28/02/2015
Director/Board Member 73 31/03/2015
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Change 5d. change 1-year change 3-years change Capi.($)
+2.79%+10.02%-12.65%-35.44% 2.85B
+0.90%0.00%+8.53%+87.92% 49.27B
+0.15%+5.49%+94.37%+13.80% 44.15B
-2.56%-6.46%+126.88%+718.87% 34.86B
-2.80%+7.30%-6.69%-26.87% 27.38B
-3.86%+0.65%+45.67%-21.71% 21.63B
-1.20%+7.18%+123.90%-46.25% 21.21B
-2.13%-6.43%+109.66%+145.68% 14.58B
-0.94%-1.93%+192.37% - 13.95B
-2.15%-8.28%-5.11%+259.79% 13.61B
Average -1.10%+1.57%+67.69%+121.75% 24.35B
Weighted average by Cap. -1.13%+1.30%+68.25%+145.40%
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Financials

2025 *2026 *
Net sales 2.67M 2.3M 2.14M 1.99M 3.7M 241M 3.97M 24.6M 9.68M 115M 10M 9.79M 423M 63.46M 54.67M 50.95M 47.4M 88.18M 5.73B 94.59M 585M 230M 2.74B 238M 233M 10.06B
Net income -515M -443M -413M -385M -715M -46.52B -767M -4.75B -1.87B -22.24B -1.93B -1.89B -81.58B -515M -444M -414M -385M -716M -46.57B -768M -4.75B -1.87B -22.26B -1.93B -1.89B -81.67B
Net Debt -609M -525M -489M -455M -847M -55.06B -908M -5.62B -2.21B -26.32B -2.29B -2.24B -96.57B -540M -465M -433M -403M -750M -48.78B -805M -4.98B -1.96B -23.32B -2.02B -1.98B -85.56B
More financial data * Estimated data
Logo Denali Therapeutics Inc.
Denali Therapeutics Inc. is a biopharmaceutical company. The Company is focused on developing a portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases and lysosomal storage disease. The Company has a portfolio of both small molecule and biotherapeutic medicines, comprising seven product candidates in clinical development across seven indications as well as preclinical therapeutic candidates. Its three late-stage development programs include tividenofusp alfa (DNL310) for mucopolysaccharidosis II (MPS II); BIIB122/DNL151 (LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (eIF2B activator) for amyotrophic lateral sclerosis (ALS). SAR443820/DNL788 (RIPK1 inhibitor) is being evaluated in a Phase II study for multiple sclerosis (MS). In addition, it has a Phase I/II study of TAK-594/DNL593 for frontotemporal dementia-granulin (FTD-GRN) and a Phase I/II study of DNL126 for MPS IIIA (Sanfilippo syndrome).
Employees
517
Calendar
More about the company
Date Price Change Volume
15/01/26 18.78 $ +2.79% 1,894,543
14/01/26 18.27 $ +0.88% 1,128,570
13/01/26 18.11 $ +0.89% 1,225,568
12/01/26 17.95 $ +5.09% 1,144,672
09/01/26 17.08 $ +0.06% 987,124

Delayed Quote Nasdaq, January 15, 2026 at 09:00 pm

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Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
18
Last Close Price
18.78USD
Average target price
32.86USD
Spread / Average Target
+74.96%
Consensus

Quarterly revenue - Rate of surprise