Valuation: Denali Therapeutics Inc.

Market Cap 3.87B 3.32B 3.1B 2.84B 5.35B 370B 5.41B 36.7B 14.27B 186B 14.52B 14.21B 615B P/E 2026 *
-10.7x
P/E 2027 * -10.5x
Enterprise Value 3.16B 2.71B 2.53B 2.32B 4.37B 303B 4.42B 29.98B 11.66B 152B 11.86B 11.61B 503B EV / Sales 2026 *
51.9x
EV / Sales 2027 * 24.1x
Free-Float
90.03%
Yield 2026 *
-
Yield 2027 * -
1 day+3.82%
1 week+3.27%
Current month+9.06%
1 month+6.51%
3 months+29.54%
6 months+12.63%
Current year+52.06%
1 week 23.41
Extreme 23.41
25.7
1 month 22.63
Extreme 22.6275
25.74
Current year 15.34
Extreme 15.34
27.3
1 year 12.58
Extreme 12.58
27.3
3 years 10.57
Extreme 10.57
33.33
5 years 10.57
Extreme 10.57
56.8
10 years 10.57
Extreme 10.57
93.94
Manager TitleAgeSince
Director of Finance/CFO 52 30/04/2022
Chief Executive Officer 50 31/07/2015
Chief Tech/Sci/R&D Officer 58 05/11/2025
Director TitleAgeSince
Director/Board Member 50 28/02/2015
Director/Board Member 73 31/03/2015
Director/Board Member 68 31/03/2015
Date Insider Type Main position Quantity % Market Cap.
12/08/26 Don

Founder

-32,220 0.0203%
11/08/26 Sell

Founder

-2,857 0.0018%
03/06/26 Free

Director

25,634 0.0162%
Change 5-day change 1-year change 3-year change Capi.($)
+3.74%+3.27%+61.24%+9.06% 3.87B
+3.31%-3.53%+71.28%+104.57% 69.06B
+1.85%+1.08%+49.05%+87.43% 63.06B
+2.83%+24.68%+10.06%-1.68% 28.34B
+1.81%-1.85%-1.74%+477.31% 27.07B
+7.41%+13.08%+58.57%+17.04% 25.45B
+3.98%+4.33%+39.41%-14.69% 19.69B
+1.02%+5.67%+273.94%+420.34% 19.19B
+0.10%+0.19%+12.19%+550.31% 15.95B
+2.71%+5.55%+47.94%+154.98% 13.52B
Average +2.86%+3.49%+62.19%+180.47% 28.52B
Weighted average by Cap. +2.81%+2.90%+59.10%+156.84%

Financials

2026 *2027 *
Net sales 60.84M 52.14M 48.78M 44.6M 84.16M 5.83B 85.05M 577M 224M 2.93B 228M 224M 9.68B 129M 111M 104M 94.69M 179M 12.37B 181M 1.23B 477M 6.21B 485M 475M 20.55B
Net income -452M -387M -362M -331M -625M -43.28B -632M -4.29B -1.67B -21.73B -1.7B -1.66B -71.91B -453M -388M -363M -332M -627M -43.39B -633M -4.3B -1.67B -21.79B -1.7B -1.66B -72.09B
Net Debt -708M -607M -568M -519M -980M -67.83B -990M -6.72B -2.61B -34.06B -2.66B -2.6B -113B -749M -642M -600M -549M -1.04B -71.69B -1.05B -7.1B -2.76B -36B -2.81B -2.75B -119B
Logo Denali Therapeutics Inc.
Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.
Employees
503
Date Price Change Volume
25/08/26 US$25.12 +3.80% 169,949
24/08/26 US$24.20 -2.89% 1,321,142
21/08/26 US$24.92 -0.12% 680,993
20/08/26 US$24.95 -2.88% 976,848
19/08/26 US$25.69 +5.68% 1,150,287
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
20
Last Close Price
24.20USD
Average target price
35.44USD
Spread / Average Target
+46.44%

Quarterly revenue - Rate of surprise

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