Valuation: Denali Therapeutics Inc.

Market Cap 3.65B 3.18B 2.96B 2.71B 5.13B 349B 5.2B 34.85B 13.68B 174B 13.72B 13.42B 582B P/E 2026 *
-9.48x
P/E 2027 * -9.49x
Enterprise Value 2.93B 2.55B 2.37B 2.18B 4.12B 280B 4.18B 27.98B 10.98B 139B 11.02B 10.78B 467B EV / Sales 2026 *
86.4x
EV / Sales 2027 * 28.4x
Free-Float
90.08%
Yield 2026 *
-
Yield 2027 * -
1 day-5.46%
1 week-0.39%
1 month-10.50%
3 months+22.97%
6 months+5.89%
Current year+39.43%
1 week 22.99
Extreme 22.99
24.68
1 month 22.01
Extreme 22.01
27.3
Current year 15.34
Extreme 15.34
27.3
1 year 12.58
Extreme 12.58
27.3
3 years 10.57
Extreme 10.57
33.33
5 years 10.57
Extreme 10.57
56.8
10 years 10.57
Extreme 10.57
93.94
Manager TitleAgeSince
Director of Finance/CFO 52 30/04/2022
Chief Executive Officer 50 31/07/2015
Chief Tech/Sci/R&D Officer 58 05/11/2025
Director TitleAgeSince
Director/Board Member 50 28/02/2015
Director/Board Member 73 31/03/2015
Director/Board Member 68 31/03/2015
Date Insider Type Main position Quantity % Market Cap.
03/06/26 Free

Director

25,634 0.0162%
10/04/26 Other

Chief Technology Officer

204,402 0.1289%
06/01/26 Sell

Founder

17,218 0.0110%
Change 5-day change 1-year change 3-year change Capi.($)
-5.46%-0.39%+66.45%-19.03% 3.65B
+2.35%+2.74%+33.41%+79.20% 56.54B
-0.21%-7.38%+25.34%+63.02% 53.6B
-2.44%+1.40%-15.74%-16.80% 22.91B
-2.85%-7.78%-8.09%+346.36% 21.37B
+2.49%-0.92%+20.31%-12.15% 20.27B
+0.79%-1.06%+29.29%-33.32% 17.56B
+0.58%-5.88%+16.30%+540.37% 14.75B
-5.25%-4.23%+46.41%+169.05% 13.33B
+3.41%-6.61%+163.08%+280.43% 13.53B
Average -0.66%-3.45%+37.67%+139.71% 23.75B
Weighted average by Cap. +0.14%-2.92%+29.25%+117.84%

Financials

2026 *2027 *
Net sales 33.97M 29.53M 27.49M 25.24M 47.65M 3.24B 48.39M 324M 127M 1.61B 128M 125M 5.41B 104M 90.11M 83.87M 77M 145M 9.89B 148M 989M 388M 4.93B 389M 381M 16.52B
Net income -479M -416M -387M -356M -672M -45.7B -682M -4.57B -1.79B -22.75B -1.8B -1.76B -76.29B -470M -409M -380M -349M -659M -44.86B -669M -4.48B -1.76B -22.33B -1.76B -1.73B -74.89B
Net Debt -720M -626M -583M -535M -1.01B -68.73B -1.03B -6.87B -2.69B -34.22B -2.7B -2.64B -115B -709M -616M -573M -526M -994M -67.64B -1.01B -6.76B -2.65B -33.67B -2.66B -2.6B -113B
Logo Denali Therapeutics Inc.
Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.
Employees
507
Date Price Change Volume
31/07/26 US$23.02 -5.46% 1,232,143
30/07/26 US$24.35 +2.10% 1,117,649
29/07/26 US$23.85 -0.83% 1,376,003
28/07/26 US$24.05 +2.04% 2,106,287
27/07/26 US$23.57 +1.99% 1,747,216
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
20
Last Close Price
23.02USD
Average target price
34.31USD
Spread / Average Target
+49.06%

Quarterly revenue - Rate of surprise

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