Blueprint Medicines Corporation Enters into a Ninth Amendment to its Collaboration and License Agreement, as Amended, with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc
January 11, 2021 at 01:21 pm
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On January 8, 2021, Blueprint Medicines Corporation entered into a ninth amendment to its collaboration and license agreement, as amended, with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. (collectively, “Roche”), related to the discovery, development and commercialization of small molecule therapeutics targeting kinases in cancer immunotherapy. Pursuant to the amendment, the Company and Roche agreed to modify certain time periods related to Roche’s option rights for one of the collaboration programs and agreed to terminate two of the other collaboration programs, including certain mechanics related to the wind-down of activities for such terminated targets. As a result of the amendment, the parties are currently conducting activities for up to two programs under the collaboration, including the previously announced program for the kinase target MAP4K1, which is believed to play a role in T cell regulation. Subject to the terms of the agreement, as amended, in addition to upfront and milestone payments previously received, the Company is eligible to receive up to approximately $323 million in contingent option fees and milestone payments related to specified research, pre-clinical, clinical, regulatory and sales-based milestones.
Blueprint Medicines Corporation is a global precision therapy company that is inventing life-changing medicines in two areas of allergy/inflammation and oncology/hematology. The Company delivers its approved medicines, including AYVAKIT/AYVAKYT (avapritinib) and GAVRETO (pralsetinib), to patients in the United States and Europe, and it is globally advancing multiple programs for systemic mastocytosis (SM), lung cancer, breast cancer and other genomically defined cancers, and cancer immunotherapy. Its pipelines also include Elenestinib (BLU-263) (KIT), AYVAKIT (avapritinib) (KIT), Wild-type KIT research program, GAVRETO (pralsetinib) (RET), BLU-945 (EGFR), BLU-525 (EGFR), BLU-451 (EGFR exon 20 insertions), BLU-222 (CDK2), AYVAKIT (PDGFRA), GAVRETO (RET), BLU-222 (CDK2) and BLU-852 (MAP4K1). It is developing elenestinib (BLU-263), an investigational, orally available, potent and highly selective KIT inhibitor, for the treatment of indolent SM and other mast cell disorders.
Blueprint Medicines Corporation Enters into a Ninth Amendment to its Collaboration and License Agreement, as Amended, with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc