Effective June 16, 2023, the Board of Directors of Zhong Yuan Bio-Technology Holdings Limited accepted the resignation of Ms. Daphne Huang from her position as a non-executive independent member of the Board of Directors of the company. The company simultaneously accepted the resignation of Ms. Huang as the chairman of the Audit Committee and as a member of the Compensation Committee and the Nomination Committee. On June 16, 2023, the Board of Directors received the consent of Dr. Chinghai Ning to serve as a non-executive independent member of the Board of Directors of the Company, determined that Dr. Ning meets the "independence" requirements of the Nasdaq listing rules and meets the independence standards under Rule 10A-3 under the Exchange Act and appointed him a non-executive independent director effective June 16, 2023.

Effective June 16, 2023, the Board of Directors removed Mr. Chi Wai Tse as the chairman of the Compensation Committee and appointed Dr. Ning as the chairman of the Compensation Committee and as a member of the Audit Committee and the Nomination Committee. Effective June 16, 2023, the Board of Directors appointed Mr. Chi Wai Tse, a current non-executive independent director of the Company, as the chairman of the Audit Committee to fill the vacancy left by Ms. Huang. The Board of Directors determined that Mr. Tse possesses sufficient accounting and related financial management experience to qualify him as an "audit committee financial expert" as defined by the rules and regulations of the SEC and further that Mr. Tse satisfies the "independence" requirements of the Nasdaq listing rules and meets the independence standards under Rule 10A-3 under the Exchange Act.

Chinghai Ning. Dr. Ning, age 51, was appointed as an independent non-executive director effective June 16, 2023. He will be responsible for providing independent judgment on issues of strategy, policy, performance, accountability, resources, key appointments and standard of conduct.

Dr. Ning is also the chairman of the Compensation Committee and a member of the Audit and Nomination Committees. Dr. Ning has over 30 years of experience serving in the medical field. While attending medical school at the University of Buenos Aires, Argentina, Dr. Ning was: (i) employed as a counselor in the Department of Biophysics from 1994-1995; (ii) assistant professor at the Department of Biophysics from 1996-1997; (iii) lab director for the Department of Biophysics from 1998-2001; and (iv) intern at the Federal Police Hospital Churruca Vizca from 1997-1999.

After graduation in 1999, Dr. Ning was employed as an associate professor of physics science in the Department of Radiology at the University of Buenos Aires, Argentina from 1999-2001, a resident physician at the Federal Police Hospital Churruca Vizca from 1999-2002 and a doctor at IOMA where he reviewed medical insurance claims from 2002-2003. From approximately 2003 through 2011, Dr. Ning was employed as a medical director at Argentina DANDT S.A., an importer and seller of medical equipment, devices and consumables, where he worked with import and wholesale, among other things. Subsequently, Dr. Ning served as the director of the purchasing department, where he was responsible for managing foreign trade, and as a vice-president responsible for the planning, strategy and design of all of the company's product marketing.

From 2011 to 2013, Dr. Ning was employed as the project supervisor of the U.S. in China at OSG Holding Corporation, where he was responsible for orchestrating financing in China. From 2013 through 2016, he was employed at Anhui ZST, an import/export company, where he was responsible for the sale of medical consumables in Latin America. Since 2016, Dr. Ning has been employed by SOMECO Electronic S.A., where he is responsible for all of China.

Dr. Ning has also been made an independent partner in that company. In addition, Dr. Ning is the chief representative of Argentina's Salta province in China where he is responsible for promoting bilateral relations and developing economic trade between the sister cities. Dr. Ning received his medical degree from the University of Buenos Aires, Argentina, in 1999.

He is a Member of the Argentina China Industry and Commerce Association.