YiChang HEC ChangJiang Pharmaceutical Co., Ltd. announced that Metoprolol Succinate Sustained-release Tablets (specifications: 47.5mg and 95mg), a product acquired by the Company from Sunshine Lake Pharma Co., Ltd., (the ``Product'') have undergone the assessment and approval process and obtained approval for launch from the China National Medical Products Administration. The marketing authorization holder of the Product is Dongguan Yangzhikang Pharmaceutical Co., Ltd. (``Yangzhikang''), a wholly-owned subsidiary of the Company. Metoprolol Succinate Sustained-release Tablets are frequently used for clinical treatment of high blood pressure and chronic heart failure.

Patients suffering from myocardial infarction and chronic heart failure and treated with Metoprolol Succinate Sustained-release Tablets for a long period of time would have lower frequency of angina pectoris and possess enhanced myocardial tolerance. Such product is a selective receptor antagonist, which can lower blood pressure and myocardial oxygen consumption by inhibiting the sympathetic nerve activity, heart rate and myocardial contractility through antagonizing1 receptor. According to market data on China from IMS, the sales of Metoprolol Succinate Sustained-release Tablets in 2020 amounted to approximately USD 280,000,000.

Metoprolol Succinate Sustained-release Tablet is one of the major drugs for the treatment of cardiovascular diseases. Metoprolol Succinate Sustained-release Tablets have considerable clinical value and market prospect and will become one of the products of the Company for the treatment of cardiovascular diseases after its launch. This can further enrich the Group's product portfolio, and will publicly provide patients with a choice of medication with high quality and fair price.

This announcement is made by the Company on a voluntary basis to keep investors informed of the latest business development of the Group, and contains no advertisement or intention regarding the use of any drug, surgical device, therapy or oral product.