Vyant Bio, Inc.'s proprietary central nervous system (CNS) drug discovery platform combines human-derived organoid models of brain disease, scaled biology, and machine learning to identify and validate drug targets and therapeutic candidates. Today, Vyant Bio announced that it will be participating at Neuroscience 2022, the 52nd Annual Gathering of the Society for Neuroscience, on November 12th-16th at the San Diego Convention Center. Vyant Bio's team will deliver two platform presentations in the Rett Syndrome Symposium presenting the identification of a repurposed drug which will be progressed into a patient trial in 2023 to demonstrate its clinical proof of concept for Rett syndrome with a differentiated mechanism of action from the most advanced Rett syndrome clinical candidates.

In addition, the Company will present a poster on the discovery of novel targets and therapeutic candidates for CDKL5 deficiency disorder (CDD) in the Stem Cell Models for Neurodevelopmental Disorders session. CDD is one of the most common forms of genetic epilepsy. Details for the presentations include: Title: Identification of a therapeutic candidate for Rett syndrome with a differentiated mechanism of action using a patient-derived cortical organoid screening platform.

Authors: Cassiano Carromeu (Presenting), Nicholas Coungeris, Neha Sodhi, Huda Ahmed, Megan Seibel, Kendra Prum, Robert Fremeau, and Andrew LaCroix Session: Rett Syndrome. Date /Time:November 16, 2022: 9:00 am PT. Title: Multiparametric analysis of coordinated network activity reveals target-specific functional rescue in a human iPSC-derived organoid model of Rett syndrome.

Authors:Andrew LaCroix (Presenting), Huda Ahmed, Nicholas Coungeris, Cameron Joseph, Neha Sodhi, Cassiano Carromeu, Robert Fremeau. Session: Rett Syndrome. Date /Time:November 16, 2022: 9:30 am PT.

Title: High-throughput functional screening to develop novel therapies for CDKL5-deficiency disorder using human iPSC-derived cortical organoids Authors: Matthew V Green, Tori Alstat, Huda Ahmed, Kendra Prum, Cassiano Carromeu, Andrew LaCroix, Robert Fremeau Session: Stem Cell Models for Neurodevelopmental Disorders. Date /Time:November 14, 2022: 1:00 pm PT. Interested parties may register for the Society for Neuroscience gathering at: Society for Neuroscience - Registration.