Onxeo S.A. announced that it has received from the U.S. Patent and Trademark Office (USPTO), a Notice Allowance for a patent which enhances in the United States the protection of AsiDNA™, its first-in-class inhibitor of tumor DNA repair, in combination with any PARP inhibitor (PARPi). This patent protects both the combination of AsiDNA™ with a PARPi and its use for the treatment of certain cancers for which the DNA repair pathway via homologous recombination (HR) is not impaired or deficient. These so-called HR-proficient tumors are significantly less sensitive to treatment with PARP inhibitors. This new patent completes, in a key territory, the already robust patent family protecting AsiDNA™ in combination with PARP inhibitors. It will provide a term of protection until 2036. The DNA repair pathways, BRCA-dependent homologous recombination pathway and PARP pathway, are complementary and essential for tumor cell survival and proliferation. If one pathway is deficient (homologous recombination by BRCA mutation) and the other is blocked by a PARP inhibitor, the tumor cell dies. This deadly combination of two genetic mutations, called synthetic lethality, is a prerequisite to PARPi efficacy. This patent is based on the fact that AsiDNA™ is able, through its original mechanism of action, to hinder DNA repair pathways, including the homologous recombination pathway. AsiDNA™ thus induces a context of "HR deficiency" needed by PARPi to be effective, regardless of the initial genetic context of the tumor.