Telix Pharmaceuticals Limited announced that the first patient has been dosed in the Company's prostate-specific membrane antigen (PSMA) targeting `ProstACT' therapeutic program, which is exploring TLX591 in areas of unmet medical need across the full prostate cancer treatment journey. Telix's ProstACT study program is evaluating the efficacy of Telix's lutetium-177 (177Lu)-labelled therapeutic antibodies in all stages of prostate cancer, from first recurrence to advanced metastatic disease (known as metastatic castrate-resistant prostate cancer, or mCRPC). The first patient, dosed at Princess Alexandra Hospital in Brisbane, Queensland, was treated as part of the ProstACT SELECT clinical trial, a Phase I radiogenomics study running concurrently to the pivotal Phase III study, ProstACT GLOBAL.

The goal of ProstACT SELECT is to compare 68Ga-PSMA (gallium-based imaging) and 177Lu-PSMA (lutetium-based therapy), specifically exploring the biodistribution and tumour uptake of small molecule and antibody-based targeting in men with PSMA-expressing mCRPC. Demonstrating the "theranostic" approach, the study is designed to inform optimal patient selection for 177Lu antibody therapy, with the goal of enabling indication expansion for Telix's PSMA therapeutic portfolio. ProstACT SELECT is a multi-centre study and will enrol up to 50 patients and is expected to take approximately 12 months to complete.