On February 26, 2015, Targeted Medical Pharma, Inc. received a letter from Dr. William E. Shell, pursuant to which he resigned as a member of the board, effective on that date. The company accepted Dr. Shell's resignation upon receipt of the resignation letter. At the time of his resignation, Dr. Shell was not a member of any committee of the board.

Dr. Shell stated that his resignation was due to numerous disputes and disagreement with the board, the company's officers and management and significant corporate shareholders relating to the company's operations, policies and practices, including the use of corporate funds.