Simulations Plus, Inc. announced that it has released Version 8.1 of its best-in-class ADMET Predictor [1]™ molecular property prediction software. This update builds upon the significant refactoring of the version 8.0 release this past summer, with a particular focus on enhancements to better serve research groups working with large data sets. Key improvements include: 64-bit version is now available; Optimization of spreadsheet and model-building functions to improve efficiency; New drug design features in the MedChem Studio Module; Rebuilt toxicity models that are more broadly applicable and Streamlined modeling using the ADMET Modeler Module'.