medicines developed by Roche are included in the World Health 
Organization Model Lists of Essential Medicines, among them life-saving 
antibiotics, antimalarials and cancer medicines. Moreover, for the 
twelfth consecutive year, Roche has been recognised as one of the most 
sustainable companies in the Pharmaceuticals Industry by the Dow Jones 
Sustainability Indices (DJSI). 
 
 
 
   The Roche Group, headquartered in Basel, Switzerland, is active in over 
100 countries and in 2019 employed about 98,000 people worldwide. In 
2019, Roche invested CHF 11.7 billion in R&D and posted sales of CHF 
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of the Roche Group. Roche is the majority shareholder in Chugai 
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https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) 
 
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https://www.euro.who.int/en/health-topics/communicable-diseases/influenza/seasonal-influenza/burden-of-influenza 
 
 
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   [13] Hayden FG, & Pavia AT. Antiviral management of seasonal and 
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Diseases Society of America: 2018 update on diagnosis, treatment, 
chemoprophylaxis, and institutional outbreak management of seasonal 
influenza. Clin Infect Dis. 2019; doi:10.1093/cid/ciy866. 
 
   [15] Wallick C, et al. Presented at: IDWeek; 2018 October 3-7; San 
Francisco. Abstract #2347. 
 
   [16] Centers for Disease Control and Prevention. What You Should Know 
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   [17] Noshi T, et al. In vitro Characterization of Baloxavir Acid, a 
First-in-Class Cap-dependent Endonuclease Inhibitor of the Influenza 
Virus Polymerase PA Subunit. Antiviral Research. 2018; 160:109-117. 
 
   [18] Taniguchi K, et al. Inhibition of avian-origin influenza A (H7N9) 
virus by the novel cap-dependent endonuclease inhibitor baloxavir 
marboxil. Scientific Reports. 2019; 9:3466. 
 
   [19] Noshi T, et al. S-033447/S-033188, a Novel Small Molecule Inhibitor 
of Cap-dependent Endonuclease of Influenza A and B Virus. 
 
   [20] In Vitro Antiviral Activity against Laboratory Strains of Influenza 
A and B Virus in Madin-Darby Canine Kidney Cells. Poster presentation at 
OPTIONS IX, August 2016. 
 
 
 
 
 
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