Investor Presentation
September 2021
1
Disclaimer
Certain information contained in this presentation and statements made orally during this presentation relate to or are based on studies, publications, surveys and other data obtained from third-party sources and Cortexyme's own internal estimates and research. While Cortexyme believes these third-party sources to be reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. While Cortexyme believes its internal research is reliable, such research has not been verified by any independent source. This presentation contains information that is highly confidential and/or privileged. The information is intended only for the use of individuals or entities to which it is addressed. If you are not the intended recipient, you are hereby notified that any reliance, disclosure, copying, distribution, or taking of any action on the contents of this material is strictly prohibited. This presentation contains forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on Cortexyme's current beliefs, expectations and assumptions regarding the future of its business, its future plans and strategies, its clinical results and other future conditions. All statements other than statements of historical facts contained in this presentation, including statements regarding future results of operations and financial position, business strategy, current and prospective markets or products, clinical activities, regulatory approvals, degree of market acceptance, and plans and objectives of management for future operations, are forward- looking statements. The words "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "estimate," "believe," "predict," "potential" or "continue" or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward- looking statements contain these identifying words. The forward-looking statements in this presentation represent Cortexyme' views as of the date of this presentation. Although Cortexyme believes the expectations reflected in such forward-looking statements are reasonable, it can give no assurance that such expectations will prove to be correct. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. Except as required by applicable law, Cortexyme do not plan to publicly update or revise any forward-looking statements contains herein, whether as a result of any new information, future events, changed circumstances or otherwise. No representations or warranties (expressed or implied) are made about the accuracy of any such forward- looking statements. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. There can be no assurance that the opportunity will meet an individual's investment objectives, or that the investor will receive a return of all or part of such investment. Investment results may vary significantly over any given time period. The appropriateness of a particular investment or strategy will depend on an investor's individual circumstances and objectives. Cortexyme recommends that investors independently evaluate specific investments and strategies.
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Game-Changing Approach Focused Upstream
Disruptive MOA
Lead Asset in Pivotal P2/3 with Data in 2021
Expanding Evidence Base
Growing Pipeline
Strong Capital Position
- Atuzaginstat is a proprietary, oral, small molecule with an MOA upstream of neurodegeneration
- Gingipain inhibitor to address the hypothesis that P. gingivalis infection is a causative agent for AD
- Completely novel class and unprecedented approach
- GAIN is fully enrolled (N=643) global pivotal Phase 2/3 clinical trial of atuzaginstat for Alzheimer's disease
- Topline results from GAIN Trial expected by mid-November 2021
- Topline results from REPAIR Phase 2 periodontal disease sub-study of 233 GAIN patients by mid-November 2021
- Expanding evidence base with animal causation and human clinical studies
- Data supports expansion into other indications
- First patient planned for Phase 2 PEAK study in Parkinson's in Q1 2022
- COR588 is a lysine gingipain inhibitor that began Phase 1 study in Q3 2021
- Lead arginine gingipain inhibitors, COR788 and COR822, have been selected
- Lead 3CLpro inhibitors, COR803 and COR817, for coronavirus treatment have been selected
- $153.5M in cash, equivalents, and short-term investments (as of June 30, 2021)
- Well-fundedto advance through multiple clinical and regulatory milestones
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Expanding Pipeline
Molecule | Target | Indication | Development Stage | Anticipated Milestones | |||
Pre-clinical | Phase 1 | Phase 2 | Phase 3 | ||||
Lysine gingipain inhibitor | Alzheimer's disease | Pivotal P2/3 GAIN trial results by mid- | |||||
November 2021 | |||||||
Atuzaginstat | Lysine gingipain inhibitor | Periodontal disease | Phase 2 REPAIR sub-study results by mid- | ||||
(COR388) | November 2021 | ||||||
Lysine gingipain inhibitor | Parkinson's disease | Phase 2 PEAK trial first patient in Q1 2022 | |||||
Periodontal and other | |||||||
COR588 | Lysine gingipain inhibitor | P. gingivalis driven | Phase 1 trial initiated September 2021 | ||||
disease | |||||||
COR788/ | Arginine gingipain | Undisclosed | |||||
COR822 | inhibitor | ||||||
COR803/ | CL3 Protease inhibitor | COVID-19 and other | |||||
COR817 | coronaviruses | ||||||
Undisclosed | Undisclosed | Undisclosed | |||||
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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease
Deepak Kumar, *Se Hoon Choi, *Kevin J. Washicosky, *William A. Eimer, Stephanie Tucker, Jessica Ghofrani, Aaron Lefkowitz, Gawain McColl, Lee E. Goldstein, Rudolph E. Tanzi, Robert D. Moir
Alzheimer's Amyloid-b is an antimicrobial peptide: a review of the evidence
Gosztyla, M.G., Brothers, H.M., Robinson, S.R. (2018). Journal
of Alzheimer's Disease, 64(4), 1495- 1506.
The Alzheimer's Disease-Associated
Amyloid β-Protein Is an Antimicrobial
Peptide
Stephanie J. Soscia, James E. Kirby, Kevin J. Washicosky, Stephanie M. Tucker, Martin Ingelsson, Bradley Hyman, Mark A. Burton, Lee E. Goldstein, Scott Duong, Rudolph E. Tanzi, Robert D. Moir
Antimicrobial Properties of
Amyloid Peptides
Bruce L. Kagan, Hyunbum Jang, Ricardo Capone,
Fernando Teran Arce, Srinivasan Ramachandran,
Ratnesh Lal, and Ruth Nussinov
"Could
Alzheimer's Stem From
Infections? It makes sense, experts
say"
Periodontal Disease and Incident
Dementia: The Atherosclerosis Risk
in Communities Study (ARIC)
Ryan T. Demmer, Faye L. Norby, Kamakshi
Lakshminarayan, Keenan A. Walker, James S. Pankow, Aaron R. Folsom, Thomas Mosley, Jim Beck, Pamela L. Lutsey
Tooth loss, dementia and neuropathology in the Nun Study
Pamela Sparks Stein, DMD; Mark Desrosiers, PhD; Sara Jean Donegan, SSND, DDS; Juan F. Yepes, DDS, MD, MPH; Richard J. Kryscio, PhD
Periodontal disease associates with higher brain amyloid load in normal elderly
Angela R. Kamer, Elizabeth Pirraglia, Wai Tsui, Henry Rusinek, Shankar Vallabhajosula, Lisa Mosconi, Li Yi, Pauline McHugh, Ronald G. Craig, Spencer
Tooth loss and Periodontal Disease Predict Poor Cognitive Function in Older Men
Elizabeth Krall Kaye, PhD, Aileen Valencia, BS, Nivine Baba, MA, Avron Spiro, III, PhD, Thomas Dietrich, DMD, and Raul I. Garcia, DMD
Serum antibodies to periodontal pathogens are a risk factor for
Alzheimer's disease
Pamela Sparks Stein, Michelle J. Steffen, Charles Smith, Gregory Jicha, Jeffrey L. Ebersole, Erin Abner, and Dolph Dawson III
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Cortexyme Inc. published this content on 15 September 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 15 September 2021 21:41:10 UTC.