OptiNose, Inc. provided revenue guidance for the first quarter and full year of 2022. The Company's expectation that first quarter 2022 XHANCE net revenue will decrease compared to fourth quarter 2021. The primary driver of the sequential decrease to revenue is the Company's expectation that XHANCE average net revenue per prescription for the first quarter of 2022 will decrease, due to typical early-year effects on price and volume related to patient insurance that the Company believes are common for chronic treatments that derive a significant proportion of total prescriptions from refills.

For full year, the Company expects XHANCE net revenues for the full year of 2022 to be at least $90 million. In addition, the Company expects XHANCE average net revenue per prescription to exceed $210 for full year 2022.