Neoleukin Therapeutics, Inc. appointed Sean Smith as the Interim Chief Financial Officer and designated him as the Company's principal financial officer, each effective as of March 31, 2023 . The Executive Officer Appointments occurred in connection with Dr. Jonathan Drachman, M.D.'s resignation from his role as President, Chief Executive Officer, principal executive and financial officer and director of the Company as of the Effective Date, as previously announced on March 6, 2023. Prior to his appointment as the Company's Interim Chief Financial Officer and designation as the Company's principal financial officer, Mr. Smith, age 37, served as the Company's Vice President, Finance and principal accounting officer since February 2022, and previously served as its Controller from October 2019 to February 2022.

From April 2017 to August 2019, Mr. Smith was at Aptevo Therapeutics Inc., a biotechnology company, where he served as Senior Manager, Accounting, and most recently as the Director of Accounting. Prior to that, Mr. Smith held various accounting, auditing, and financial reporting leadership roles at a public company within the telecommunications industry and at KPMG. Mr. Smith holds a Bachelor of Science in Accounting and a Master of Science in Accounting, both from the University of North Texas, and a Master of Business Administration from the University of Washington.

Mr. Smith is also a Certified Public Accountant.