Positive interim results from
There are several benefits of the combination vaccine as a preventative measure against these respiratory conditions, according to the pharmaceutical company. For example: higher patient compliance, easier administration and greater convenience.
Data from
The ongoing Phase I/II clinical trial is evaluating the safety and immunogenicity of mRNA-1083 compared to a standard dose of the influenza vaccine Fluarix, in adults aged 50-64. Additionally, the combination vaccine is being investigated against Fluzone HD, an enhanced influenza vaccine, in adults 65-79 years of age. According to
mRNA-1083 achieved hemagglutination inhibition antibody titers similar to or greater than both licensed quadrivalent influenza vaccines. Moreover, the combination vaccine achieved SARS-CoV-2 neutralising antibody titers similar to the Spikevax bivalent booster in the Phase I/II study,
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The company also noted that the mRNA vaccine achieved:
- Geometric mean titer (GMT) ratios >0 relative to Fluarix in adults 50-64 years of age, for all four influenza vaccine strains
- mRNA-1083 GMT ratios relative to Fluzone HD in adults aged 65-79 were also >0. This was the case for all four influenza vaccine strains
- GMT ratios of mRNA-1083 relative to Spikevax bivalent were >9 in adults between 50 and 64 years old and >1.0 in adults 65 to 79 years of age, relative to Spikevax.
“We are excited to move combination respiratory vaccines into Phase III development,” stated
mRNA researchers awarded 2023 Nobel Prize
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