On December 16, 2022, Carol L. Brosgart, M.D., notified the board of directors of Mirum Pharmaceuticals, Inc. of her resignation as a director of the Company and as a member of the Nominating and Corporate Governance Committee of the Board, effective December 19, 2022. Following Dr. Brosgart's resignation, she plans to assume a new role as the Company's senior advisor in science and policy.