MegaPro Biomedical Co., Ltd. and China Chemical & Pharmaceutical Co., Ltd. jointly announced an agreement with Wellbridge Biotech Ltd. to sign a compact to establish a joint venture company - Trium Therapeutics Co., Ltd. MegaPro will hold 30% of Trium, CCPC will hold 40%, and Wellbridge will hold a 30% stake; the chairman and general manager will be appointed by CCPC and MegaPro respectively. MegaPro states that the newly established Trium will focus on the development of new drugs in new dosage forms of inhalation dosage forms.  In recent years, pharmaceutical companies have been looking for non-invasive routes of administration (such as nasal cavity or lung) to improve the patients' convenience and comfort when taking medicines, while increasing the bioavailability of the principal components.  This has become a popular field of current pharmaceutical preparation, and it is also the main research and development goal of the three companies' joint venture to establish Trium. According to a market survey report on inhalers by DATA BRIDGE, a professional research machine, the market size is expected to reach 42.1 billion US dollars by 2027, with a compound annual growth rate of 5.87%.  The growth mainly results from the fact that as patients inhale preparations into the lungs, the main components of the drug can be quickly absorbed due to the characteristics of the large contact area of the lungs and the densely positioned blood capillaries within, which allows the main components of the drug to be quickly absorbed.  This can greatly improve the convenience and therapeutic effect of drug usage, and in addition to the simplicity and convenience of using inhalation dosage forms, related applications of inhaled dosage forms are expected to continue to flourish in the coming years.

MegaPro states that in this collaboration case, the company will use its expertise in improving drug delivery technology in new drugs in new dosage forms to develop various dosage forms of inhaled preparations through nano-platform technology, and it also plans to carry out relevant animal experiments and human clinical trials; CCPC owns GMP-producing pharmaceutical factories and sales channels at home and abroad. In the future, it will be responsible for the mass production and preparation of drugs required for clinical trials and the marketing of medicines once it enters the market in the future; Wellbridge is a Chinese company that specializes in medical nebulizers which would provide technical information required for the development of inhalation dosage forms, in addition to the supplying required equipment for inhalation dosage forms. Trium has now completed the screening of drug candidates and indications and the preliminary animal tests. In the future, research and development processes such as stability tests, scale-up, GLP animal tests, and clinical phase I trials of related drugs are to be carried out according to the planned schedule.