* Data for datopotamab deruxtecan (DS-1062) and Enhertu signal strong potential of these antibody drug conjugates in advanced lung cancer New non-small cell lung cancer data for Tagrisso and Imfinzi further demonstrate the impact of treating patients in early stages of the disease
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Presentations include:
Updated data from the TROPION-PanTumor01 Phase I trial of datopotamab deruxtecan (Dato-DXd; DS-1062) with additional patients, supporting its potential to redefine treatment outcomes in advanced non-small cell lung cancer (NSCLC). Datopotamab deruxtecan is a novel trophoblast cell-surface antigen 2 (TROP2)-directed antibody drug conjugate (ADC)
New data from the DESTINY-Lung01 Phase II trial highlighting the potential of Enhertu (trastuzumab deruxtecan) in HER2-expressing metastatic NSCLC, and data in metastatic HER2-mutant (HER2m) NSCLC, two groups of patients for whom no HER2-directed medicine is currently approved
New analyses from the ADAURA Phase III trial featured in two oral presentations reinforcing the unprecedented benefit of Tagrisso (osimertinib) regardless of prior adjuvant chemotherapy or disease stage in the adjuvant treatment of epidermal growth factor receptor-mutated (EGFRm) NSCLC, and showing patients treated with Tagrisso maintained their quality of life
Harnessing the emerging potential of ADCs to treat different types of lung cancer
Updated data from the TROPION-PanTumor01 Phase I trial of the novel ADC datopotamab deruxtecan will be featured in an oral presentation, demonstrating early antitumour activity in patients with advanced/metastatic NSCLC who had progressed on standard treatment. Additionally, two presentations on the data from the DESTINY-Lung01 Phase II trial will show results of Enhertu patients with NSCLC, including new data from the HER2-expressing cohort and data from the HER2 mutant cohort.
Collaboration in the scientific community is critical to improving outcomes for patients.
Treating patients with NSCLC in early stages
A late-breaking analysis from the ADAURA Phase III trial will underscore the practice-changing results for adjuvant Tagrisso in Stage IB-IIIA EGFRm NSCLC and show the disease-free survival benefit for patients who had been treated with adjuvant chemotherapy prior to Tagrisso and those who were not by stage of disease. A second exploratory analysis from the Phase III ADAURA trial will highlight the impact of treatment with adjuvant Tagrisso on quality of life based on patient-reported outcomes. Tagrisso was recently approved in the adjuvant setting in the US.
The ongoing NeoADAURA Phase III trial testing the benefit of treating patients with resectable EGFRm NSCLC with neoadjuvant Tagrisso will be highlighted in a poster presentation.
The MERMAID-1 Phase III trial testing Imfinzi (durvalumab) in patients with completely resected, Stage II and III NSCLC who show evidence of minimal residual disease (MRD), will also be highlighted in a poster. MERMAID-1 is an early-stage NSCLC Phase III trial evaluating circulating tumour DNA measurements to monitor for MRD and to identify patients at high risk of recurrence after surgery who may benefit from intervention with immunotherapy.
Progressing research in advanced lung cancer
Additional data from the
The biomarker-directed HUDSON Phase II platform trial of Imfinzi in combination with Lynparza (olaparib) and other novel anti-cancer medicines, including danvatirsen (STAT3 antisense oligonucleotide), ceralasertib (ATR inhibitor) and oleclumab (anti-CD73), in patients with NSCLC who progressed on anti-PD(L)1 therapy
The ODIN BM Phase I trial assessing Tagrisso brain exposure in patients with EGFRm NSCLC central nervous system (CNS) metastases
The TATTON Phase Ib trial of Tagrisso plus savolitinib in patients with EGFRm MET-overexpressed/amplified NSCLC
A trial-in-progress update on the Phase I trial of Tagrisso in combination with patritumab deruxtecan (HER3-DXd; U3-1402) in patients with locally advanced or metastatic EGFRm NSCLC
Key-
The Company is also evaluating the potential of ADCs to improve patient outcomes in tumours with targetable gene alterations, including HER2m NSCLC which affects approximately 2-4% of patients with NSCLC.4,5 Enhertu, a HER2-directed antibody drug conjugate, is in development for metastatic non-squamous HER2-overexpressing or HER2m NSCLC including trials in combination with other anticancer treatments. In addition, a broad and comprehensive clinical development programme is evaluating the efficacy and safety of datopotamab deruxtecan (a TROP2-directed ADC) across multiple TROP2 cancers, as both a monotherapy and in combination with other anticancer treatments.
An extensive Immuno-Oncology (IO) development programme focuses on lung cancer patients without a targetable genetic mutation, which represent up to three-quarters of all patients with lung cancer.6 Imfinzi, an anti-PDL1 antibody, is in development for patients with advanced disease (POSEIDON and PEARL Phase III trials) and for patients in earlier stages of disease, including potentially curative settings (MERMAID-1, MERMAID-2, AEGEAN, ADJUVANT BR.31, PACIFIC-2, PACIFIC-4, PACIFIC-5, and ADRIATIC Phase III trials) both as monotherapy and in combination with tremelimumab and/or chemotherapy. Imfinzi is also in development in the NeoCOAST, COAST and HUDSON Phase II trials in combination with potential new medicines from the early-stage pipeline, including Enhertu.
By harnessing the power of six scientific platforms - Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response, Antibody Drug Conjugates, Epigenetics, and Cell Therapies - and by championing the development of personalised combinations,
References
1. Szumera-Cieckiewicz A, et al. EGFR mutation testing on cytological and histological samples in non-small cell lung cancer: a Polish, single institution study and systematic review of European incidence. Int J Clin Exp Pathol. 2013;6:2800-12.
2. Keedy VL, et al.
3. Ellison G, et al. EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples. J Clin Pathol. 2013;66:79-89.
4. Campbell JD, et al. Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.
5. Li BT, et al. HER2 amplification and HER2 mutation are distinct molecular targets in lung cancers. J Thorac Oncol. 2016;11(3): 414-419.
6. Pakkala, S, et al. Personalized therapy for lung cancer: striking a moving target. JCI Insight. 2018;3(15):e120858.
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