Dai ichi Life : Impact Investment in PaMeLa Co., Ltd.- Contributing to Improving Patients' Quality of Life through Development of Medical Device That "Visualizes" Pain Using Brain Waves - PDF

September 29, 2021

Impact Investment in PaMeLa Co., Ltd.

• Contributing to Improving Patients' Quality of Life through Development of Medical Device That
  "Visualizes" Pain Using Brain Waves -

The Dai-ichi Life Insurance Company, Limited (the "Company"; President and Representative Director: Seiji Inagaki) has invested approximately JPY 100 million in PaMeLa Co., Ltd. ("PaMeLa"; President and Representative Director: Arata Hasegawa), a Japanese startup that develops and provides a medical device that scientifically measures pain using brain waves. This impact investment1 is a part of the Company's ESG investments.

• A startup that has spun off from Osaka University and is developing a medical device that can objectively measure and evaluate pain, a subjective sensation
• The technology developed by PaMeLa analyzes brain waves using artificial intelligence to quantify pain, thereby making it possible to conduct pain evaluations with universal indicators, even for different patients
• Objectively evaluating pain makes it possible to properly administer analgesics, which is anticipated to contribute to an improvement in patients' quality of life. Examples of such improvement include
  lessening the number of patients with chronic pain whose pain endures due to the underdosage of analgesics, the

inhibition of symptoms of addiction resulting from the overdosage of analgesics, and the like.

[Social Impact]

			The development and supply of a medical device which can objectively
Improvement of			measure and evaluate pain makes it possible to appropriately administer
patients' quality of life			analgesics and the like, thereby realizing an improvement in patients'
			quality of life

Through this investment, the Company not only expects a high level of returns, but will provide capital support for the initiatives of PaMeLa, which are expected to improve patients' quality of life (social impact). Further, the Company will continuously monitor the progress of these initiatives.

As a responsible institutional investor, the Company will continue to actively engage in ESG investment to realize a sustainable society as well as to improve its investment returns through sophisticated and diverse investment methods.

1Impact investment is an investment method where an investor makes investment decisions with the intent to gain investment returns and generate social impact (e.g., structural change in society).

1

Mr. Arata Hasegawa, President and Representative Director of PaMeLa Co., Ltd., made the following remarks:

			We are a university spinoff startup engaged in medical device development, formed in order to
			socially implement the research results of Specially Appointed Professor Aya Nakae of Osaka
			University's Graduate School of Frontier Biosciences. Just as there are clinical thermometers for
			body temperature and sphygmomanometers for blood pressure, by providing a method for
			measuring pain in the form of a medical device, we are striving toward a society in which
			measuring pain is an everyday occurrence. The current pain evaluation method used in medical
			care is a subjective method called VAS (visual analogue scale), which is conducted via self-
			reporting. In contrast, we use an objective method which quantifies pain by using a small
			electroencephalograph to measure brain waves and using AI to analyze the quantity of pain
			characteristics. The first application involved usage as a medical device in pain management
			following surgery; and we have set our sights on home usage in the future. We will contribute to
			improving the quality of life of people suffering from pain by developing a medical device which
			contributes to appropriate pain treatment.
		[Company Outline]
		Trade Name	PaMeLa Co., Ltd.
		Head Office	E601 Osaka University Biosystems Building 6F, 1-3 Yamadaoka, Suita, Osaka 565-0871, JAPAN
		Representative	Arata Hasegawa, President and Representative Director
		Established	February 2016
		Business	Accumulation of clinical research data regarding analgesic	effects and product development of
		Description	electroencephalograph which automatically displays patients' pain
		Dai-ichi Life's Impact Investment History
	Headline				Release			URL
				Date
	Dai-ichi Life to Engage in Impact Investment						https://www.dai-ichi-
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	BioM aterials -							pdf
	Dai-ichi Life to Investment in CureApp, Inc.						https://www.dai-ichi-
			Feb. 26, 2018			life.co.jp/english/news_release/2017/pd
	- Third Impact Investment through Support for Treatment Applications -
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	Dai-ichi Life to Impact Invest in CROWD CREDIT, Inc.						https://www.dai-ichi-
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	Dai-ichi Life to Impact Invest in SUSM ED, Inc.						https://www.dai-ichi-
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	Dai-ichi Life to Impact Investment in M ELTIN M MI						https://www.dai-ichi-
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- Shortening of pharmaceutical development through the world's first antibody	Nov. 27, 2018	life.co.jp/english/news_release/2018/pd
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Dai-ichi Life to Impact Invest in QD Laser			https://www.dai-ichi-
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Dai-ichi Life to Impact Invest in Challenergy Inc.			https://www.dai-ichi-
- Helping to reduce CO2 emissions using the world's first wind turbine capable of	Feb. 28, 2019	life.co.jp/english/news_release/2018/pd
generating electricity even in typhoons -			f/index_012.pdf
Dai-ichi Life to Impact Invest in Venture Fund managed by Energy & Environment		https://www.dai-ichi-
Investment, Inc.
		M ar. 20, 2019	life.co.jp/english/news_release/2018/pd
- Japan's Only Independent Venture Capital Focused on the Energy and Resource
	f/index_015.pdf
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- Support Social Impact	Creator and Investment	Recipient CureApp, through	Nov. 29, 2019	life.co.jp/english/news_release/2019/pd
Investment in Anti-Smoking Project -			f/index_021.pdf
Dai-ichi Life to Impact Invest in M odulus Discovery, Inc.		https://www.dai-ichi-
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Impact Investment in RIVERFIELD Inc.			https://www.dai-ichi-
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