- CRB-913 is a novel highly peripherally restricted CB1 inverse agonist with potent monotherapy efficacy in DIO mouse model
- Weight loss and related outcomes markedly enhanced in combination with tirzepatide, semaglutide or liraglutide
Separately, a manuscript of the selected study, titled Novel CB1R Inverse Agonist CRB-913 Enhances Efficacy of Tirzepatide, Semaglutide and Liraglutide in the DIO Mouse Model (Morningstar, et al), will also be published in the November edition of Obesity, the scientific journal of
“These data point to the potential of CRB-913, both as a monotherapy in combination with incretin therapies,” said
The pre-clinical study evaluated the anti-obesity effects of CRB-913, a peripherally restricted inverse agonist as monotherapy and in combination with incretin analogs (tirzepatide, semaglutide, or liraglutide) in a diet induced-obesity (DIO) mouse model. CRB-913 demonstrated markedly enhanced plasma exposure and markedly reduced brain levels compared to the first generation CB1 inverse agonist rimonabant. CRB-913 monotherapy yielded dose-dependent decrease in body weight in DIO mice that was further enhanced in combination with tirzepatide, semaglutide, or liraglutide. Concomitantly, improvements were observed in body fat content, leptinemia, insulin resistance, liver triglycerides, liver fat deposits and liver histology. All changes were statistically significant. CRB-913 did not induce any loss of lean mass. Investigators concluded that CRB-913, in combination with incretin analogs, could potentially deliver meaningful improvements in obesity and related conditions.
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INVESTOR CONTACT:
Chief Financial Officer
smoran@corbuspharma.com
Managing Director
bmackle@lifesciadvisors.com
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