Brii Biosciences announced new data from two Phase 1 studies in healthy volunteers in the U.S., which evaluated long-acting BRII-732 and BRII-778, both drug candidates in development for the treatment of human immunodeficiency virus (HIV) infection. Results from both studies show that once-weekly BRII-732 and BRII-778 are safe and well-tolerated, generating important data to support the ongoing development of a potential first-in-class oral once-weekly combination therapy to treat HIV. The findings from these studies were presented in two poster sessions at IDWeek 2022.

One of the posters presented at IDWeek titled, Safety, Tolerability, and Pharmacokinetics of BRII-732, A Medoxomil Carbonate Prodrug of Islatravir in Healthy Adult Subjects, highlights that oral BRII-732 demonstrated an acceptable safety and tolerability profile following single ascending dose (SAD) up to 200 mg and multiple ascending dose (MAD) up to 25 mg, as well as a favorable and linear pharmacokinetic (PK) profile that achieved therapeutic targets. These data reinforce potential development of BRII-732 as part of a combination antiretroviral therapy, inclusive of once-weekly dosing. A second poster at IDWeek titled, Safety, Tolerability, and Pharmacokinetics of BRII-778, A Modified-Release Oral Formulation of Rilpivirine in Healthy Adult Subjects, demonstrates that SAD and MAD administration of BRII-778 formulations are generally safe and well-tolerated with PK profiles consistent with slower oral absorption, providing key insights for ongoing clinical evaluation and development of BRII-778 as part of a potential once-weekly regimen for the treatment of HIV.

In addition, three of the Brii's strategic development partners are presenting a total of 16 abstracts at IDWeek 2022 related to assets under co-development with the Company. This collective presence at IDWeek underpins the robust scientific progress across Brii's anti-infectives portfolio designed to tackle a broad range of infectious diseases that present significant public health burdens to people around the world. As part of these partnerships, Brii holds licensing rights to advance multiple therapeutic candidates in Greater China for multi-drug resistant (MDR) and extensive drug resistant (XDR) gram-negative infections with Qpex Biopharma, as well as non-tuberculosis mycobacteria with AN2 Therapeutics.