September 28, 2022
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This presentation contains forward-looking statements that involve substantial risks and uncertainties. Forward-looking statements include statements regarding future results of operations and financial position, business strategy, product candidates, planned preclinical studies and clinical trials, results of clinical trials, research and development costs, regulatory approvals, timing and likelihood of success, plans and objectives of management for future operations, as well as statements regarding industry trends. Such forward-looking statements are based on ALX Oncology's beliefs and assumptions and on information currently available to it on the date of this presentation. Forward-looking statements may involve known and unknown risks, uncertainties and other factors that may cause ALX Oncology's actual results, performance or achievements to be materially different from those
expressed or implied by the forward-looking statements. These and other risks are described more fully in ALX Oncology's filings with
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ALX ONCOLOGY (NASDAQ: ALXO) ADVANCING A HIGHLY DIFFERENTIATED IMMUNO-ONCOLOGY PIPELINE LED BY EVORPACEPT, A CD47 INNATE IMMUNE SYSTEM CHECKPOINT INHIBITOR
Evorpacept: designed to maximize a patient's immune response
Acts on CD47 as a checkpoint inhibitor, a key mechanism tumors use to evade the immune system
- Activates the immune system without eliminating healthy cells that express CD47
Demonstrated activity in both solid and liquid tumors
- Three ongoing randomized Phase 2 studies underway in solid tumors
- Two studies underway in combination with antibody drug conjugates (ADCs)
- Hematology studies ongoing
Potential cornerstone treatment for a broad range of cancers
Continuing to build a pipeline based on expertise in protein engineering and oncology
• 2023 IND planned for ALTA-002*
- Early preclinical development of ADC platform.
Strong financial position
- Expected cash runway through
the fourth quarter of 2024.
- Cash, cash equivalents and investments of $324.2M as of June 30, 2022.
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* Through 50/50 joint collaboration.
EVORPACEPT'S DESIGN ENABLES BROAD POTENTIAL UTILITY IN COMBINATION WITH MANY TYPES OF CANCER THERAPY
Modality | Target | Evorpacept clinical trials | ||
▪ | HNSCC | |||
I/O | PD(L)1 | ▪ | CRC* | |
▪ | Ovarian* | |||
HER2 | ▪ | Gastric | ||
▪ | Breast | |||
Targeted mAbs | CD20 | ▪ | NHL | |
▪ | Follicular* | |||
EGFR | ▪ | CRC* | ||
ADCs | Nectin-4 | ▪ | Urothelial | |
HER2 | ▪ | Breast | ||
Chemo | AZA | ▪ | MDS | |
▪ | AML | |||
*Investigator sponsored trial
Ongoing early and late stage clinical trials designed to demonstrate expansive clinical opportunity in many tumor types
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ALX PIPELINE
Indication
HNSCC | ||
Head AndNeck Squamous Cell | ||
Studies | TUMORS | Carcinoma |
Junction Cancer | ||
GC | ||
Combination | Gastric/Gastroesophageal | |
SOLID | Urothelial Cancer | |
Evorpacept | HEMATOLOGY | Breast Cancer |
NHL | ||
MDS | ||
Myelodysplastic Syndromes | ||
AML | ||
Acute Myeloid Leukemia | ||
Non-Hodgkin's Lymphoma | ||
ALTA 002* | Advanced Cancer | |
Combination Agent | Discovery | IND Enabling | Phase 1 | Phase 2 | Phase 3 | Fast Track | Collaboration |
Partner | |||||||
Keytruda | |||||||
(ASPEN-03) | |||||||
Keytruda + 5FU + Platinum | |||||||
(ASPEN-04) | |||||||
Herceptin | |||||||
(ASPEN-01) | |||||||
Herceptin + Cyramza + | |||||||
Paclitaxel (ASPEN-06) | |||||||
Padcev | |||||||
(ASPEN-07) | |||||||
Zanidatamab | |||||||
Enhertu | |||||||
(I-SPY) | |||||||
Azacitidine | |||||||
(ASPEN-02) | |||||||
Azacitidine + Venclexta | |||||||
(ASPEN-05) | |||||||
Rituximab | |||||||
(ASPEN-01) |
*SIRPα Toll-like receptor agonist antibody conjugate (TRAAC)
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ALX Oncology Holdings Inc. published this content on 28 September 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 28 September 2022 11:15:05 UTC.