On September 2, 2021, the Board of Directors of Adverum Biotechnologies, Inc. appointed Jack Thrift as Adverum’s Interim Chief Financial Officer. Mr. Thrift also assumed the role of Principal Financial Officer and Principal Accounting Officer of Adverum. Mr. Thrift replaces Chris DeRespino in these roles who, as previously announced, left Adverum on August 27, 2021. Mr. Thrift, was appointed as Interim Chief Financial Officer on September 2, 2021. Since March 2016, Mr. Thrift has served as Partner with DeBruin & Thrift Accountancy Group, LLC, in which role he is responsible for outsourced CFO services to a variety of clients. On September 6, 2021, Adverum’s Chief Technology Officer, Angela Thedinga, informed Adverum that, as part of a move to Boston, Massachusetts for family reasons, she is planning to separate from Adverum over time. The timing and other terms of her departure have not been determined.