Waters Corporation introduced the first in a new line of size exclusion chromatography (SEC) columns aimed at improving the analysis while lowering the cost of gene therapies, specifically adeno-associated viral (AAV) vectors. The new Waters? XBridge?

Premier GTx BEH? SEC columns doubles the speed of measuring the potency and safety of AAVs. Combining the columns with light scattering technologies from its Wyatt Technology portfolio deepens the level of information acquired from a single experiment and optimizes the manufacturing of these novel gene delivery vehicles.

AAVs are modified viruses made in bioreactors by living cells and are the number one vehicle for carrying therapeutic genes into human cells. Waters scientists have developed a fast and efficient multi-attribute quantification methodiv of characterizing AAVs that features the following Waters products: ACQUITY? Premier UPLC?

Systems or Arc? Premier HPLC Systems; XBridge Premier GTx BEH SEC 450Å 2.5 µm columns; Arc Premier 2489 UV/Visible detector or 2998 photodiode array detector; Wyatt? DAWN?

multi-angle light scattering detector; and Wyatt Optilab? differential refractive index detector. XBridge Premier GTx BEH SEC columns are now available worldwide from Waters.