Tengion, Inc. announced continued clinical progress in its two lead programs, the Neo-Kidney Augment and the Neo-Urinary Conduit. The Neo-Kidney Augment, which is intended to prevent or delay dialysis and transplantation by increasing renal function in patients with advanced chronic kidney disease (CKD), was implanted in five CKD patients in 2013 in the ongoing Phase 1 clinical trial in Sweden. The Neo-Kidney Augment is safe and well tolerated in the five patients implanted to date.

The Company now plans to expand enrollment in this trial to 15 patients. The Company also announced the initiation of a Phase 1 clinical trial in the U.S. under an open Investigational New Drug (IND) application for the Neo-Kidney Augment. Tengion will also complete patient enrollment in the ongoing U.S. Phase 1 clinical trial for its second lead program, the Neo-Urinary Conduit, an autologous implant that is intended to catalyze regeneration of native-like urinary tissue for bladder cancer patients requiring a urinary diversion following bladder removal.

The Phase 1 trial of the Neo-Kidney Augment being conducted at the Karolinska Institute in Stockholm, Sweden commenced in May 2013 and involves delivery of an active regenerative dose of Neo-Kidney Augment in patients with CKD. The Neo-Kidney Augment is safe and well tolerated in the five patients implanted to date. As noted above, the Company plans to expand enrollment to 15 patients, and all patients in the trial will be followed for up to two years.