The use of lipid-based nanoparticles offers significant advantages in drug delivery, boosting bioavailability, reducing toxicity and enabling the administration of therapeutics that are prone to instability. Therapeutics that would benefit from nanoparticle delivery systems require custom lipids to create novel formulations to optimize delivery and release of their payload. “Cayman’s team of synthetic organic and medicinal chemists specialize in building high-purity, GMP-quality components (phospholipids, sterols, sphingolipids, PEGylated lipids, glycerolipids, anionic lipids, and cationic lipids) used to assemble a lipid nanoparticle,” said
The development of a lipid-based nanoparticle delivery system in part requires morphological characterization such as evaluation of particle size, shape, and surface details. “NanoImaging Services has been providing cryoEM services for the visualization of viral and lipid nanoparticles since 2007 and offers a range of characterization services including qualitative and quantitative analysis to help support drug delivery and vaccine development projects,” said
Once developed, these lipid nanoparticles must be formulated for eventual clinical use. T&
“This triad partnership provides Cayman clients a one-stop shop for lipid nanoparticle development - from R&D to final formulation. We have always offered services for custom synthesis of complex lipids, but by now also coordinating lipid nanoparticle formulation and characterization,” said Dr.
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