Item 1.01 Entry Into a Material Definitive Agreement

On January 21, 2022, Synlogic Operating Company, Inc. ("Synlogic OpCo"), a wholly-owned subsidiary of Synlogic, Inc. (the "Company"), entered into two Statements of Work (the "SOWs") with Azzur Cleanrooms-On-Demand - Boston, LLC, ("Azzur") pursuant to a License and Services Agreement (the "License Agreement"), effective as of April 28, 2021, by and between Synlogic OpCo and Azzur.

Pursuant to the first of the SOWs (the "First SOW"), Synlogic OpCo has agreed to pay Azzur $650,000 to renovate and upgrade Azzur's cleanroom space in Waltham, Massachusetts (the "Azzur Suite") for Synlogic OpCo's expanded use. The second of the SOWs (the "Second SOW") replaces a previous SOW that Synlogic OpCo entered into with Azzur on April 29, 2021 (the "Previous SOW"). Pursuant to the Previous SOW, Synlogic OpCo was granted access to, and use of, the Azzur Suite for a period of 20 months, from May 2021 to December 2022 (the "Previous Term"). A copy of the Previous SOW is attached as an exhibit to the Company's Quarterly Report on Form 10-Q for the quarter ending June 30, 2021. The Second SOW replaces the Previous SOW for the period beginning January 2022 and extends the Previous Term through March 2023 (the "Term"). The total estimated project cost during the Term for access to, and use of, the renovated and upgraded Azzur Suite, and the personnel support and other services, is $2.4 million.

The summary of the First SOW and Second SOW is qualified in its entirety by reference to the full text of the First SOW and the Second SOW, copies of which will be attached as exhibits to the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2021.

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