SOPHiA GENETICS SA announced an expanded suite of solutions under SOPHiA DDM? for Liquid Biopsy. The range of solutions, including MSK-ACCESS® powered with SOPHiA DDM?

and custom solutions, will help progress oncology research and tumor mutation profiling. The rollout of SOPHiA GENETICS' liquid biopsy capabilities demonstrates the company's commitment to developing advanced solutions that empower timely, critical decision-making and improve health outcomes. For a sizeable number of cases, genomic testing of tumor tissue is not feasible due to either insufficient tissue material, low quality of the obtained tissue, or the invasiveness of the procedure.

Liquid biopsy testing offers an alternative to solid tumor testing by isolating cell-free DNA (cfDNA) from blood plasma, which may uncover circulating tumor DNA (ctDNA). Isolating these DNA samples from a simple blood draw can help guide clinical decisions in a manner that is faster and less invasive, expedite results for researchers and clinicians, and simplify monitoring. SOPHiA GENETICS' liquid biopsy offering will help users enhance tumor profiling with advanced cfDNA analysis and a streamlined DNA-only NGS workflow, allowing users to go from extracted cfDNA to comprehensive report in an efficient timeframe.

SOPHiA DDM? for Liquid Biopsy features SOPHiA GENETICS' proprietary unique molecular identifier technology (CUMIN?) that is designed to transform the way labs analyze cell-free DNA samples with exceptional performance and reliable results. Customers interested in implementing a liquid biopsy offering via SOPHiA DDM?

have different options based on their individual needs. MSK-ACCESS® powered with SOPHiA DDM? is a decentralized version of a highly validated ctDNA assay developed by Memorial Sloan Kettering (MSK) that involves the deep sequencing of 146 key cancer-associated genes.

Customers utilizing the SOPHiA DDM? Platform for solid tumor applications can adapt their panels to include liquid biopsy samples; and for customers who have unique challenges or who focus on specific biomarkers, SOPHiA GENETICS offers custom liquid biopsy applications built in partnership with the SOPHiA GENETICS team.