The board of directors of Shanghai Henlius Biotech, Inc. announced that Mr. Guo Xinjun (?Mr. Guo?) has tendered his resignation from the positions as the secretary to the Board and a joint company secretary of the Company with effect from 5 November 2021. Mr. Guo will continue to act as a senior vice president of the Company. Mr. Guo has confirmed that he has no disagreement with the Board and there are no matters relating to his resignation that need to be brought to the attention of the shareholders of the Company and The Stock Exchange of Hong Kong Limited (the "Stock Exchange"). The Board announced that it has approved the appointment of Ms. Wang Yan ("Ms. Wang") as the secretary to the Board and a joint company secretary of the Company, with effect from 5 November 2021. Ms. Wang, aged 34, joined the Company in July 2013 and has successively acted as Science & Technology Administrative Commissioner, Supervisor of the Marketing Department, Securities Affairs Representative and Manager of Public Affairs Department, director of the Office of Board Secretary and executive director of Public Relationship of the Company. Ms. Leung will work closely with Ms. Wang to jointly discharge the duties and responsibilities as the company secretaries of the Company and to assist Ms. Wang to acquire the relevant experience as required under the Listing Rules for a period of three years from the effective date of Ms. Wang's appointment.