Seer, Inc. announced an expanded collaboration with Thermo Fisher Scientific to enable broader access to each company's respective new technologies. As part of the collaboration, Seer will establish the Seer Technology Access Center to showcase its latest product, the Proteograph XT Assay Kit, in combination with Thermo Fisher's newest mass spectrometer, the Thermo Scientific Orbitrap Astral mass spectrometer (MS). The combination of Proteograph XT and Orbitrap Astral MS will deliver unprecedented depth and scale in complex biological samples, with over 6,000 protein IDs and over 54,000 peptide IDs per sample from human plasma, paving the road for population-scale studies with unprecedented biological insight.

The Seer Technology Access Center will address an important unmet need for researchers who do not have access to mass spectrometry, but wish to undertake deep unbiased proteomics studies, such as translational and genomics researchers performing population-scale studies with deep molecular profiling. As part of the collaboration, Seer and Thermo Fisher will develop and optimize proteomics and proteogenomics workflows, including the integration of data and analysis protocols. The Seer Technology Access Center will provide mass spectrometry services on the Thermo Scientific Orbitrap Astral MS to new Proteograph XT customers, as well as end-to-end solutions to customers who are looking for access to the biological insight that can only be gained from deep, unbiased proteomics.

The Seer Technology Access Center will launch in the summer of 2023 with multiple Proteograph Product Suites running the Proteograph XT Assay on multiple Orbitrap Astral mass spectrometers. With each Proteograph Product Suite running the Proteograph XT Assay, hundreds of samples per week can be processed on a fully automated workflow with minimal hands-on time and less than one hour of mass spec time per sample. The combined workflow increases both throughput and performance substantially, lowering the cost per data point, thereby enabling more labs to access the power they need to unlock the potential of the proteome.

Under this collaboration, Seer and Thermo Fisher will prioritize demonstrating the clinical utility of mass spec-based proteomics in large cohort studies spanning cancer, metabolic and neurodegenerative disease. Seer initially partnered in 2021 with Thermo Fisher to offer its Proteograph Product Suite on Thermo Fisher's Thermo Scientific Orbitrap Eclipse Tribid MS and Thermo Scientific Orbitrap Exploris 480 MS systems to provide customers with a complete proteomics workflow. Seer currently uses both platforms in its development efforts and market development programs.