Saniona AB announced top line results from its exploratory Phase 2a clinical trial for Tesomet in patients with Prader-Willi syndrome. The small number of patients in the study (n=9) and the failure of one placebo and four treated patients to complete the study preempts statistical evaluation. Surprisingly, plasma concentrations of tesofensine were found to be two to four times higher in this study compared to previous studies in obese and diabetic patients with the same tesofensine dose. This may explain the high dropout rate in the study and some of the observed side effects. The exploratory, double-blind, randomized, placebo-controlled Phase 2a trial enrolled a total of nine adult patients with Prader-Willi syndrome, of which six patients received Tesomet and three patients received placebo. A total of four patients completed the trial (two on treatment and two on placebo). A total of seven patients completed eight weeks of the study (five on treatment and two on placebo). Overall, the results must be interpreted with caution.