- Pivotal data on glofitamab, a potential first-in-class CD20xCD3 T-cell engaging bispecific antibody, in heavily pre-treated patients with aggressive lymphoma, will be presented as part of our industry-leading haematology portfolio
- Further studies exploring broad genomic testing to support informed treatment decisions for patients and advance cancer care approaches will be presented
“At ASCO this year, progress from our portfolio, partnerships and collaborations showcase our commitment to advance innovation in cancer care,” said
Focusing on improving outcomes in non-Hodgkin lymphoma
New and updated data in non-Hodgkin lymphoma will be presented at ASCO. This includes pivotal data from the phase II NP30179 study evaluating glofitamab, an investigational CD20xCD3 T-cell engaging bispecific antibody, in heavily pre-treated patients with diffuse large B-cell lymphoma (DLBCL). DLBCL is an aggressive form of lymphoma, where as many as 40% of patients will relapse, at which point treatment options are limited and survival is shortened.1,2 Glofitamab is part of Roche’s broad bispecific antibody development programme, which may offer a new immunotherapy-based approach to tackle a range of blood cancers. It is being investigated in several clinical trials including the STARGLO phase III study, evaluating glofitamab in combination with gemcitabine and oxaliplatin (GemOx) versus MabThera®/Rituxan® (rituximab) in combination with GemOx in autologous stem-cell transplant ineligible relapsed or refractory DLBCL. In addition, key findings from an analysis of the
Driving innovation in personalised cancer care
More than 20 new pieces of research from partnerships with Foundation Medicine will be presented, which continue to support innovation as well as progress in personalised cancer care. This includes new data from the phase II Profiler02 study,* which investigates the use of a comprehensive genomic profiling testing panel from Foundation Medicine, with the aim of informing possible treatment decisions for patients based on their tumour’s unique genomic information.
Data from the imCORE network
Additionally, three abstracts from the Immunotherapy Centers Of Research Excellence (imCORE) Network will be presented at ASCO: a phase I study investigating autogene cevumeran (an mRNA-based individualised neoantigen-specific immunotherapy [iNeST]***) in the adjuvant setting of pancreatic ductal adenocarcinoma;** a data mining study evaluating intermediate endpoints for survival in metastatic breast cancer in the real-world setting;** and a study identifying mechanisms of acquired resistance to immune checkpoint blockade.**
imCORE is an academic-industry network for scientific collaboration. Established by
Roche’s data presented at ASCO will feature its efforts to drive innovation and commitment to health equity through delivery of pioneering medicines and personalised cancer care that together improve outcomes for every patient while reducing the cost to society, inclusive clinical trials that remove barriers to participation, partnerships that multiply our ability to address challenges in cancer care, and bringing innovation into earlier stages of disease to maximise a chance of cure.
Roche Oncology Newsroom
Roche’s Oncology Newsroom will be available to journalists from 24 May and feature exclusive materials providing insights into Roche’s vision, the latest data and perspectives on health inequities in cancer care. To access the Newsroom, please register here.
Overview of key presentations featuring
Medicine | Abstract title | Abstract number |
Blood cancer | ||
Glofitamab | Glofitamab in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and ≥2 prior therapies: Pivotal phase II expansion results. | #7500 |
Mosunetuzumab | CELESTIMO: a phase III trial evaluating the efficacy and safety of mosunetuzumab plus lenalidomide versus rituximab plus lenalidomide in patients with relapsed or refractory follicular lymphoma who have received ≥1 line of systemic therapy. | #TPS7588 |
Polivy | #7558 | |
Initial safety run-in results of the phase III POLARGO trial: polatuzumab vedotin plus rituximab, gemcitabine, and oxaliplatin in patients (pts) with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). | #7551 | |
Lung cancer | ||
Tiragolumab | SKYSCRAPER-02: primary results of a phase III, randomized, double-blind, placebo-controlled study of atezolizumab (atezo) + carboplatin + etoposide (CE) with or without tiragolumab (tira) in patients (pts) with untreated extensive-stage small cell lung cancer (ES-SCLC). | #LBA8507 |
Breast cancer | ||
Giredestrant | Neoadjuvant giredestrant (GDC-9545) plus palbociclib (P) versus anastrozole (A) plus P in postmenopausal women with estrogen receptor-positive, HER2-negative, untreated early breast cancer (ER+/HER2– eBC): final analysis of the randomized, open-label, international phase 2 coopERA BC study. | #589 |
Inavolisib | Long-term safety of inavolisib (GDC-0077) in an ongoing phase 1/1b study evaluating monotherapy and in combination (combo) with palbociclib (palbo) and/or endocrine therapy in patients (pts) with PIK3CA-mutated, hormone receptor-positive/HER2-negative (HR+/HER2–) metastatic breast cancer (BC). | #1052 |
Tumour agnostic treatment and personalised healthcare | ||
Rozlytrek | Efficacy/safety of entrectinib in patients (pts) with ROS1-positive (ROS1+) advanced/metastatic NSCLC from the Blood First Assay Screening Trial (BFAST). | #LBA9023 |
Rozlytrek | Trial in progress: a randomised phase 3 study of entrectinib versus crizotinib in patients (pts) with locally advanced/metastatic ROS1 fusion-positive (fp) NSCLC with or without baseline CNS metastases (mets). | #TPS9141 |
Comprehensive genomic profiling (IIS, Centre | Increasing targeted therapy options for patients with relapsed cancer with broader somatic gene panel analysis from the primary tumor: The Profiler02 randomized phase II trial.* | #3130 |
Comprehensive genomic profiling | Clinical and genomic characteristics of patients with durable benefit from immune checkpoint inhibitors (ICI) in advanced non-small cell lung cancer (aNSCLC). | #9048 |
Comprehensive genomic profiling | CtDNA Shed as a Tool to Select Immune Checkpoint Inhibitors (ICPI) with or without Chemotherapy for Patients (pts) with advanced Non-small Cell | #9045 |
Comprehensive genomic profiling | Trial in progress - LCMC LEADER Neoadjuvant Screening Trial: LCMC4 Evaluation of Actionable Drivers in Early Stage Lung Cancers. | #TPS8596 |
Real world data | A real-world (rw) evidence study quantifying the clinical value of multi-gene testing in early-stage lung adenocarcinoma (LUAD). | #8525 |
Real world data | Real-world analysis of quantitative MET copy number (CN) as a biomarker in NSCLC (NSCLC). | #9123 |
Real world data | Ancestry-based differences in gene alterations in non-small cell lung cancer: real-world data using genetic ancestry analysis. | #9125 |
imCORE, ISR, | Identifying mechanisms of acquired immune escape from sequential, paired biopsies.** | #2519 |
imCORE ISR, | Real-World Progression-Free Survival (rwPFS) and Time to Next Line of Therapy (TTNT) as Intermediate Endpoints for Survival in Metastatic Breast Cancer: a real world Experience.** | #6520 |
imCORE ISR, | Phase I Trial of Adjuvant Autogene Cevumeran, an Individualized mRNA Neoantigen Vaccine, for Pancreatic Ductal Adenocarcinoma.** | #2516 |
* IIS, investigator-initiated study
** ISR, institution-sponsored research
*** jointly developed by
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References
[1] Maurer MJ, Ghesquières H, Jais JP, et al. Event-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with immunochemotherapy. J Clin Oncol. 2014;32(10):1066-1073.
[2] Sehn LH, Gascoyne RD. Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity. Blood. 2015;125(1):22-32.
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