ProMIS’ proprietary drug discovery and development platform highlighted for ability to create novel antibodies, diagnostics and vaccine candidates for neurodegenerative diseases
Proteins that misfold and aggregate to form toxic oligomers in the central nervous system are considered a root cause of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). These diseases lack effective therapies in large part because classical drug discovery and development approaches cannot selectively target the toxic oligomer with adequate precision. At this inaugural conference, intended to help shift this drug design and discovery paradigm,
The ProMIS platform relies on a proprietary blend of physics, biology and supercomputing to rapidly and cost-effectively identify unique binding sites, called disease-specific epitopes (DSEs), on complex protein structures. ProMIS uses these DSEs to create peptide antigens, which are novel drug development tools that precisely mirror the sequence and shape (conformation) of these DSEs. This unique process enables the creation of antibody and vaccine candidates and potential diagnostics that are selective for the toxic form of proteins responsible for disease. Presently, the ProMIS portfolio in neurodegenerative diseases includes antibody therapeutic candidates for AD, PD and ALS, in addition to the recently announced development of a multivalent vaccine for AD.
“Protein misfolding is a root cause of multiple neurodegenerative diseases, as well as other disease states such as certain cancers,” said Dr.
Protein Misfolding Drug Discovery 2020 will occur virtually on
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