Item 8.01 Other Events.

On January 5, 2023, Orchard Therapeutics plc issued a press release titled "Orchard Therapeutics Announces U.S. FDA Clearance of IND Application for OTL-203 in MPS-IH." A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.



Exhibit
Number                                     Description
99.1          Press release, dated January 5, 2023
104          Cover page interactive data file (embedded within the Inline XBRL document)

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