OptiBiotix Health : Results Report

HALF YEARLY REPORT

FOR THE SIX MONTHS ENDED 30 JUNE 2021

Chairman's and Chief Executive's Statement

For the six months to 30 June 2021

We are pleased to present OptiBiotix Health plc's interim results for the six month period ended 30 June 2021.

Trading during the first six months of this year has been strong. The Group saw sales of LPLDL® and SlimBiome® as an ingredient or final product of £1.076m, representing a 44.5% increase over the H1 period last year.

Each division continues to make progress with sales in ProBiotix of £536,225, up 57.5% (H1 2020: £340,429), PreBiotics sales of £539,819, up 35.6% (H1 2020: £398,271), and a 4.8% increase in margins compared to the same period last year. As in previous years, there was no substantive contribution in the period from license or royalty payments which tend to be received in the second half of the year. The Group believes it is in a strong position to meet or exceed its full year sales forecast.

The strong sales growth is especially pleasing given the continued uncertain global economic environment and challenges of the subsequent waves of COVID-19, particularly in countries like India and the USA, in the first six months of the year.

Strategic overview

OptiBiotix operates in the human microbiome space, an exciting area of healthcare expected to grow at a CAGR of over 22% between 2020 and 2025 (Mordor Intelligence 2019). The Group is at a strategic inflection point with brand recognition and growing sales from its global network of partners from its lead first generation products and early commercial traction with its second generation products. First generation products were designed with a low development risk with the aim of establishing the Group and its products whilst second generation products are step changes in innovation, which if successful, have a large potential upside. The Group continues to build value through both sets of products and its holding in separately listed SkinBioTherapeutics plc (SBTX).

The Group is making strong progress against the aims it set out in the first half of the year:-

1. Growing sales with existing partners by extending product lines and territories. These include:-
2. 1. The launch of Bioslim, a Very Low-Calorie Diet (VLCD) weight management product with Arrotex Pharmaceutials, Australia's

largest privately owned pharmaceutical company and the Optiman brand containing OptiBiome in July 2021 with Optipharm

1. 1. The extension of Holland & Barretts SlimExpert own brand range of SlimBiome® from three to eight in March 2021.
   2. Territory expansion for DS-01 containing LPLDL® with Seed Health to support their ambitious growth plans.
2. Growing sales with large partners in key strategic markets (e.g India, China, USA etc).
3. 1. These bring volume sales, international reach, and enhance brand credibility but take longer to negotiate given the often lengthy due diligence process.

III. Changing the sales mix to increase sales of final products.

IV. Renegotiating costs of goods as volumes increase to gain volume discounts.

1. Commercialising its next generation products including microbiome modulators (MM's) biotherapeutics, and its growing family of SweetBiotix® products.

Our first generation products are now increasingly becoming associated with international retail and pharmaceutical partners and established brands, which create further interest, and demand in other markets. As we grow sales and profitability in our first generation products, extend our reach into new application areas and territories, and commercialise next generation products the scale of our opportunity enlarges. Consumer and industry interest in the microbiome and 'gut health' is growing and its link with a wide range of chronic illnesses is becoming more defined. OptiBiotix is well placed to exploit this emerging opportunity with its products and with it the potential for a significant enhancement in the value of the Group.

Commercial Overview

The Group provided a commercial update in August (RNS: 5/8/21) and as such this section provides a general update on areas not previously covered. The Group is increasing brand and product awareness in key strategic markets and has signed deals with Compson Biotechnology (Taiwan), INSCOBEE INC (South Korea) and Bioscience Marketing (Malaysia) - all for LPLDL®/CholBiome®. These agreements have been reached to build LP LDL® and CholBiome's reputation and brand awareness in Asia and open up the potential for cross boarder e-commerce trading in China. hese agreements are complemented by the launch of SlimBiome Metablic Support on TMall in Taiwan with MaxCare in May 2021. TMall is part of the Alibaba group, an online platform which allows both Chinese and international companies to sell their products in mainland China, Hong Kong, Macau, and Taiwan, and the 3rd most visited website in the world and the 1st most visited website in China https://en.wikipedia.org/wiki/Tmall. These create multiple routes of entry into the large and complex Chinese market.

Half Yearly Report 2021 1

Chairman's and Chief Executive's Statement (continued)

We are particularly pleased with the large number of industry, retail nominations, and awards, we have won for our products in different territories around the world Figure 1.

Industry awards increase brand and product awareness which in turn increases partners' interest, leading to OptiBiotix being recognised as a key player in the global microbiome market in a number of industry reports.

Investors will note the gradual migration of the Group's awards and nominations from science to ingredients, and increasingly to final products, as we look to provide more high value differentiated final solutions. This focus will continue throughout 2021 and into 2022 in line with our strategy of growing LPLDL® and SlimBiome® as ingredients brands through a business to business (B2B) network of partners giving us the confidence to invest in building our own brand finished product solutions (e.g. GoFigure, CholBiome, SlimBiome Medical) with our ingredients at the core. Sales of final product typically have higher prices and margin increasing turnover and profitability and act as a pull through for ingredient sale creating a dual effect. As the Group moves towards a greater focus on direct to consumer final product sales it will increase its investment in product marketing.

RESULTS

OptiBiotix results for six months ended June 30 2021 are set out below.

The results show revenue for the six months of £1.076m (2020: £744,821) representing a 44.5% increase over the H1 period last year and ahead of the Group's expectations for the first six months of the year.

Each division continues to make progress with sales in ProBiotix of £536,225, up 57.5% (H1 2020: £340,429) and PreBiotics sales of £539,819, up 35.6% (H1 2020: £398,271) compared to the same period last year with gross margins increasing from 39.2% to 44%. As in previous years, there was no substantive contribution in this period from license or royalty payments which tend to be received in the second half of the year and increase margins. The Group has renegotiated a number of agreements with both suppliers and customers in H1 2021 which will impact on margins in H2 and more substantially in full year 2022 and beyond.

Administrative expenses were £1,071,015 (2020: £896,268) with £174,780 non-cash expenses representing depreciation, amortisation and share based payment charges (2020: £162,840). The increase in administrative expenses (£174,747) was a result of one-off recruitment and search fees for René Kamminga, an innovations director, a business development director for North America, and consultancy fees for Chris Nother plus additional staff costs (£52,000 ) for Dr Taru Jain (Business Development Director Asia) and Aneta Zlotkowska (Head of Quality). Despite these costs, of which £117,000 are not recurring, the operating loss for the first six months of the year was £596,784, a small decrease on the same period last year (2020: £599,194). This was compensated for by proceeds of £900,936 (H1 2020: £746,751) received from the disposal of shares in SkinBioTherapeutics plc ('SBTX') giving a net trading

• OptiBiotix Health Plc

profit of £110,893. This figure does not include any change in the value of the Group's SBTX investment which has increased from £8,962,564 as of 31 December 2020, to £22,947,992 as of June 30 2021.

As at 30 June 2021, the Group had a £993,014 cash balance. Once R&D tax credits are claimed and recoverable VAT repayments are added, the balance would be £1.21m

BOARD AND MANAGEMENT

We continue to evolve the management team and Board in line with the stage of the Group's development with a number of additions to the board and executive team since the start of the year. These are all part of a number of changes reflecting the transition of the Group into a commercial business and increased focus on selling final products solutions into high value markets which value science, clinical studies, and intellectual property.

Christopher Brinsmead CBE and Stephen Hammond MP joined the Board as non-executive directors at the start of the year bringing senior executive experience in the pharmaceutical, healthcare, fund management and investment banking sectors respectively. Dr Taru Jain joined OptiBiotix's management team in March 2021 to focus on business development and growing sales in the strategically important Indian and Asian markets. She has over 10 years of experience across the Indian healthcare value chain as well as primary knowledge of the demand pattern of the prescription and pharmacy over the counter (OTC) market.

René Kamminga joined as Chief Executive Officer ("CEO") of OptiBiotix Ltd, a wholly owned subsidiary of OptiBiotix Health plc in April 2021 and brings more than 25 years' experience in the sale of speciality ingredients and products. Rene joined us from the position of Vice President of Business Development and Chief Commercial Officer of the Nutraceuticals division of KD Pharma Group where he was integral in developing and delivering on a strategy of moving the business from bulk ingredients to finished product solutions. The appointment of Rene as CEO of OptiBiotix Ltd, and search for a CEO of ProBiotix Health Ltd reflects the group's strategy in appointing experienced industry business leaders who can take ownership of the strategy, P&L responsibility, and development of the business into a highly profitable and major player in the microbiome market in the years ahead.

The Group also appointed Christopher Nother on a six-monthpart-time consultancy basis to support the growth of LPLDL® in pharma, either as an OTC product used by itself or in combination with existing treatments (e.g. statins), or a drug biotherapeutic in markets outside the USA. Chris identified opportunities in taking OTC products like the CholBiome range into the high value evidence based pharmaceutical market and continues to work for OptiBiotix on a success fee basis.

We anticipate further additions and changes to both the executive and non-executive team in-line with the continued growth and expansion of the Group. These are likely to include a development/innovations

director, a business development director for the strategically important North American market, a CEO for ProBiotix Health, and a scientific and technical support specialist. Aneta Zlotkowska, Head of Quality & Operations, will be leaving us at the end of the year as the Group completes its BRC certification.

These changes are all part of a strategy to bring in industry leaders and specialist expertise to support the Group's growth plans and capitalise on the opportunities created by our growing pipeline of products.

The Group has identified the retention and attraction of key personnel staff as a principal risk as reported in its 2020 annual report. As interest in the microbiome grows and competitor companies look to either acquire businesses or expertise this risk increases. The Group has commissioned PWC to review its existing arrangements and develop proposals to mitigate the risk and align value creation with remuneration consistent with companies on the AIM market at a similar stage of development.

OUTLOOK

The Group is in a strong position to meet or exceed its full year sales forecast as it continues to build brand awareness and expand sales of its first-generation products whilst building the scientific and clinical evidence base needed to de-risk its innovative second-generation products. We are particularly pleased with the number of partners extending their product ranges (Optipharm, H&B) and territories (Optipharm, Seed Health) which shows confidence in the products and brand and helps to grow a recurring revenue base providing a foundation on which to build a valuable and sustainable business.

The Group has a clear direction of travel in its two-stage strategy of building brand presence and early sales of its first generation LPLDL® and SlimBiome® products whilst parallel tracking the development of its more innovative second-generation products offering potentially larger returns. The strategy has been designed with the divisions acting as the commercial arms of the Group led by industry leaders focused on building sales and profitability whilst the Group acquires and develops technologies to build the product pipeline providing the scientific and clinical studies, publications and regulatory approvals. Having two separate wholly owned product legal entities within the Group plc (OptiBiotix Limited and Probiotix Health Ltd) and a substantive investment in a third, (SBTX), gives OptiBiotix shareholders a position in multiple opportunities within the emerging microbiome space. As each of these divisions grow revenues and profitability there is potential for an independent exit or separate listing as has been achieved with Skinbiotherapeutics plc (SBTX). As part of this process of building financial independence of each division and the shift towards final product solutions we are integrating consumer goods costs and sales into the divisional structures. This will give a more accurate reflection of each divisions trading position as an independent legal entity and reduce the possibility of creating conflict between B2B and B2C partners as OptiBiotix sells more final product solutions.

Half Yearly Report 2021 3

Chairman's and Chief Executive's Statement (continued)

As we move through 2021, we will continue to grow revenues, manage costs, improve margins, and invest in extending opportunities for our first generation products markets and drive the commercialisation of our exciting second generation products with manufacturing and application partners. We will continue to explore opportunities for LPLDL® in high value pharmaceutical markets, where science and clinical studies are highly valued, and extend its reach into new application areas. These include funding a PhD studentship and clinical study into the role of the microbiome in stress, anxiety, and sleep disorders with the University of Southampton and University of Trento, and continuing to develop applications for LPLDL® in dairy, which represents over 85% of the global probiotic market. We are starting to see the benefits of achieving FDA GRAS, with our partner in Uruguay, Grancha Pocha, launching a yoghurt containing LPLDL® in H2, and Sacco growing sales of LPLDL® with dairy customers around the world. We see similar growth opportunities for SlimBiome® by extending the range of products containing SlimBiome® with existing and new partners, and leveraging our industry recognition as an innovator in the microbiome field by developing new applications for the health and wellbeing and the sports nutrition market.

Internationally, having established manufacturing partners in India, we anticipate commercial progress in this market in H2 2021, and potentially in other key strategic markets such as China and the USA, although these will take more time to develop fully. We are particularly focused on large companies who are leading brands in healthcare, hospitals, pharma, healthcare or E-commerce within their own country, or with our second generation products on global partners in manufacturing or producers of dairy, beverage, or consumer products who could benefit from replacing existing sugar or sweeteners with healthier options. The key partner characteristics are country recognition and a network which allows the opportunity to quickly scale up sales if the products are successful.

The continued strong growth in our revenues in H1 2021 is encouraging as the Group builds a recurring revenue base which is increasing as partners launch new products, extend territories, and build brand presence. We believe these product launches, the extension of territories with existing partners, the prospect of agreements with corporate partners in key strategic markets, the continuing flow of new agreements and product launches, the growing realisation of the development pipeline, and the strengthening of our Board and senior management with industry expertise, allows us to look forward with confidence to the further progress of the Group in the current year and beyond.

As we consider the future, we are pleased to see growing consumer and industry interest in the human microbiome presenting us with a market opportunity that is large and expanding. OptiBiotix has had over 100 items of coverage in industry journals, trade magazines, feature magazines etc to the end of August 2021. These are not always seen by investors as they are industry focused given the B2B nature of the

current business but are important in establishing OptiBiotix and its products as innovators in the industry and attracting partner interest. As we shift the focus from ingredients to final product solutions we will direct our marketing efforts at the consumer and have a number of radio interviews planned throughout cholesterol month in October.

We are particularly pleased that a number of large partners have identified the presence of scientific and clinical studies and an extensive IP portfolio as key differentiating features in this evolving market, and OptiBiotix as a priority partner as they look to enter the microbiome space. The Group is ideally positioned to exploit these opportunities with first generation products which impact on major chronic lifestyle diseases, industry recognition as a key industry player in the microbiome space, and next generation products of SweetBiotix® and MM's providing a step change in existing sugar and sweeteners and the potential to modify the microbiome in a highly targeted way. Our family of SweetBiotix® products has attracted a lot of industry interest with a US partner bearing the costs for product manufacturing one type of SweetBiotix® whilst paying annual royalty fees. This is a clear indication of the precommercial value placed on this step change in technology. After a number of technical challenges we were particularly pleased to achieve progress in the first half of the year with our MM's, which should allow us to manufacture these at scale. This creates the potential to manufacture prebiotic products which can change the relative abundance of specific microbial species linked to disease. If the microbiome is the future of healthcare then the ability to precision engineer the microbiome and change the relative amounts of specific bacteria in a highly targeted way is an important step in developing products which can prevent or treat disease and/or enhance the effectiveness of existing drug treatments.

We look forward to growing sales of first generation products as we scale our business model and strengthen our position in this new and exciting area of science which has the potential to revolutionise the future of healthcare.

On behalf of everyone at OptiBiotix Health we would like to thank our investors for their continued support and look forward to an exciting future.

N Davidson and S O'Hara

30 September 2021

• OptiBiotix Health Plc