Novamind Inc. announced it is enrolling participants in a phase II clinical trial sponsored by Alto Neuroscience ("Alto"), a clinical stage company focused on pioneering the field of precision psychiatry. The eight-week clinical trial currently underway at Novamind's Draper, Utah research site is investigating an antidepressant medication for adults with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) (the "Alto Clinical Trial"). Novamind is collecting real-world data from participants ages 18 to 64 years old which includes electroencephalography (EEG), behavioural task performance on a range of neurocognitive tasks, sleep and activity indices collected from wearable devices, and genetic data to identify correlated responses to the drug candidate ("ALTO-100").

The Alto Clinical Trial leverages machine learning, Alto's brain biomarker platform and precision psychiatry approach to identify patient phenotypes that demonstrate the greater response to ALTO-100. The Alto Clinical Trial adds to Novamind's established track record hosting clinical trials and research studies for various mental health conditions, including Merck & Co.'s MK-1942 for treatment-resistant depression; Bionomics' BNC210 for post-traumatic stress disorder; and Karuna Therapeutics' KarXT for schizophrenia. Prior to joining Novamind as Chief Medical Officer, Dr. Reid Robison played a lead role in the pivotal ketamine study for treatment-resistant depression by Janssen, leading to FDA approval of Spravato.