- CStone to acquire exclusive rights for development and commercialization outside
South Korea for LCB71, an ROR1 antibody drug conjugate - Agreement adds to CStone's pipeline a potential first-in-class/best-in-class drug candidate with monotherapy and combination applications for a range of cancer indications
- LCB71 has demonstrated preclinical efficacy and reduced toxicity
Under the agreement, CStone obtains the exclusive global right to lead development and commercialization of LCB71 outside the
LCB71 is a pre-clinical ADC entering into Investigational New Drug ("IND") enabling studies. It targets ROR1 (receptor tyrosine kinase-like orphan receptor 1), a high-potential ADC target for multiple solid and hematological malignancies. ROR1 protein expression is prevalent in a variety of cancers including various forms of leukemia, non-Hodgkin lymphoma, and breast, lung, and ovarian cancers.
LCB71 has a proprietary tumor-activated pyrrolobenzodiazepine ("PBD") prodrug toxin that addresses the typical toxicity problem associated with traditional PBD payloads. It has demonstrated complete tumor inhibition across several preclinical cancer models, which may translate into a wide therapeutic index for a range of solid and hematologic malignancies. Additionally, it utilizes site-specific conjugation for a precise drug antibody ratio. This supports serum half-life and improves its pharmacokinetic profile, and also enables homogeneous production and large-scale manufacturing.
Dr.
About CStone
CStone is a biopharmaceutical company focused on developing and commercializing innovative immuno-oncology and precision medicines to address the unmet medical needs of cancer patients in
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CSTONE INVESTOR CONTACT
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