Primary liver cancer (PLC), also known as liver carcinoma, is one of the common gastrointestinal malignancies worldwide. Approximately 85%-90% of liver cancers were hepatocellular carcinoma (HCC)1. GLOBOCAN survey in 2020 found that 906 thousands of new cases were diagnosed and 830 thousand deaths world-wide each year, which took the sixth position out of malignancies and the 3rd leading cause of cancer death2. The 5-year survival rate was 15%-19% in
This first-in-human study of JWATM204 aims to evaluate the safety, tolerability, dose limited toxicity and pharmacokinetic profile of JWATM204 in adult subjects with advanced HCC, and also to explore the anti-tumor activity of JWATM204 in the target population. The promising preclinical results showed continued clinical development potential of JWATM204 for the treatment of HCC.
JWATM204, with high affinity and specificity of GPC-3 monoclonal antibody and developed at the ARTEMIS® T-cell platform, is an innovative immune T-cell therapy targeting glypican-3 (GPC-3).
References
1. 肝细胞癌免疫治疗中国专家共识,2021年,中华医学杂志2021 年12月28日第101 卷第48期
2.
3. CSCO原发性肝癌诊疗指南,2020年, 中国临床肿瘤学会指南工作委员会,人民卫生出版社
About JWATM204
JWATM204, with the high affinity and specificity of GPC-3 monoclonal antibody developed at the ARTEMIS® T-cell platform, is an innovative immune T-cell therapy targeting GPC-3. GPC-3, a member of the glypican-related integral membrane proteoglycan family, is overexpressed in multiple malignancies including HCC, but not or lowly expressed in normal organs, including normal liver organs or cirrhosis liver. GPC-3 is expressed in 72% of HHC patients1. GPC-3 holds its oncogenic effect through Wnt pathway2. GPC-3 has become a popular target for HCC due to its high sensitivity and specificity. The ARTEMIS® T cell platform, with intracellular regulatory mechanism similar to TCR-T cell therapy and precision of CAR-T therapy, is expected to significantly reduce or even eliminate cytokine release syndrome (CRS) associated with T cell over activation and other life-threatening cytokine-related toxicities. With the assistance of co-stimulatory molecules on the surface of T cells, sufficient T cell activation signals can be generated, which can promote T cell activation and strengthen the antitumor activity.
References:
1. Capurro M, Wanless IR, Sherman M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89–97.
2. Kolluri A and Ho M. The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer. Front. Oncol. 2019, 9:708.
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[1] ALLEMANI C, WEIR HK, CARREIRA H, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25, 676, 887 patients from 279 population-based registries in 67countries (
[2] TORRE LA,
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