The data were presented in an oral late-breaker session at the
'Chronic hepatitis B represents a significant healthcare challenge for which there is particular need for new treatments that provide a longer-lasting solution. Data from the Phase 2b B-Clear study demonstrated the potential of bepirovirsen to provide rapid reductions in hepatitis B surface antigen in both patients not on nucleoside analogue treatment and those on stable NA therapy. These findings, together with results of previous clinical studies, support GSK's plan to initiate a Phase 3 clinical study evaluating bepirovirsen,' said
In the study, 28% of patients on standard of care, which is stable nucleoside/nucleotide analogue (NA), and 29% of patients not on NA treatment, experienced a virologic response (VR) on 300 mg of bepirovirsen weekly, following 24 weeks of treatment. Virologic response is defined as serum/plasma levels of hepatitis B virus (HBV) DNA and hepatitis B surface antigens (HBsAg) below the lower limit of quantification. Up to 68% of patients on NA therapy and up to 65% of patients not on NA achieved HBsAg
(C) 2022 Electronic News Publishing, source