Hemogenyx Pharmaceuticals : Proxy Form (2023 AGM)

Hemogenyx Pharmaceuticals plc

*00000101010010*

000001

MR A SAMPLE

< DESIGNATION> SAMPLE STREET SAMPLE TOWN SAMPLE CITY SAMPLE COUNTY AA11 1AA

Please detach this portion before posting this proxy form.

Attendance Card

Please bring this card with you to the Meeting and present it at Shareholder registration/accreditation.

Additional Holders:

ADDITIONAL HOLDER 1

ADDITIONAL HOLDER 2

ADDITIONAL HOLDER 3

ADDITIONAL HOLDER 4

The Chairman of Hemogenyx Pharmaceuticals plc invites you to attend the Annual General Meeting of the Company to be held at

the offices of Peterhouse Capital Limited, 80 Cheapside, London EC2V 6DZ on 30 June 2023 at 2.00 pm BST.

Shareholder Reference Number

C0000000000



Form of Proxy - Annual General Meeting to be held on 30 June 2023

To be effective, all proxy appointments must be lodged with the Company's Registrars at:

Computershare Investor Services PLC, The Pavilions, Bridgwater Road, Bristol BS99 6ZY by 28 June 2023 at 2.00 pm.

Explanatory Notes:

1. Every holder has the right to appoint some other person(s) of their choice, who need not be a shareholder, as his proxy to exercise all or any of his rights, to attend, speak and vote on their behalf at the meeting. You are strongly encouraged to appoint "the Chair of the meeting" as your proxy in case the arrangements for the AGM need to change to be a "closed meeting" and an alternative proxy cannot attend in person. If you wish to appoint a person other than the Chairman, please insert the name of your chosen proxy holder in the space provided (see reverse). If the proxy is being appointed in relation to less than your full voting entitlement, please enter in the box next to the proxy holder's name (see reverse) the number of shares in relation to which they are authorised to act as your proxy. If returned without an indication as to how the proxy shall vote on any particular matter, the proxy will exercise his discretion as to whether, and if so how, he votes (or if this proxy form has been issued in respect of a designated account for a shareholder, the proxy will exercise his discretion as to whether, and if so how, he votes).
2. To appoint more than one proxy, an additional proxy form(s) may be obtained by contacting the Registrar's helpline on 0330 303 1185 or you may photocopy this form. Please indicate in the box next to the proxy holder's name (see reverse) the number of shares in relation to which they are authorised to act as your proxy. Please also indicate by marking the box provided if the proxy instruction is one of multiple instructions being given. All forms must be signed and should be returned together in the same envelope.
3. The 'Vote Withheld' option overleaf is provided to enable you to abstain on any particular resolution. However, it should be noted that a 'Vote Withheld' is not a vote in law and will not be counted in the calculation of the proportion of the votes 'For' and 'Against' a resolution.
4. Pursuant to Regulation 41 of the Uncertificated Securities Regulations 2001, entitlement to attend and vote at the meeting and the number of votes which may be cast thereat will be determined by reference to the Register of Members of the Company at close of business on the day
   days before the day of the meeting. Changes to entries Members after that time shall be disregarded in reallyLongword andmore

determining the rights of any person to attend and vote at the meeting.

1. To appoint one or more proxies or to give an instruction to a proxy (whether previously appointed or otherwise) via the CREST system, CREST messages must be received by the issuer's agent (ID number 3RA50) not later than 48 hours before the time appointed for holding the meeting. For this purpose, the time of receipt will be taken to be the time (as determined by the timestamp generated by the CREST system) from which the issuer's agent is able to retrieve the message. The Company may treat as invalid a proxy appointment sent by CREST in the circumstances set out in Regulation 35(5)(a) of the Uncertificated Securities Regulations 2001.
2. The above is how your address appears on the Register of Members. If this information is incorrect please ring the Registrar's helpline on 0330 303 1185 to request a change of address form or go to www.investorcentre.co.uk to use the online Investor Centre service.
3. Any alterations made to this form should be initialled.
4. The completion and return of this form will not preclude a member from attending the meeting and voting in person.
5. Instructions for Accessing the Webcast - Shareholders will be given the opportunity to access the AGM and subsequent shareholder update remotely and submit written questions at the AGM via a webcast conducted over video conference call. Shareholders can register for the video conference call by visiting https://tinyurl.com/hemo2023 and completing the registration form. You will receive an email with instructions on how to access the video conference call. You are advised to register in advance of the day of the meeting to ensure that you receive the instructions in good time. Access to the AGM will be available from 2.00 p.m. BST on 30 June 2023. Shareholders wishing to raise any questions relating to the business of the AGM may do so by submitting them to the Chair by email to [e-mail]
   advance of the AGM.

Kindly Note: This form is issued only to the addressee(s) and designated account printed hereon. This personalised form is different: (i) account holders; or (ii) uniquely designated accounts Computershare Investor Services PLC accept no liability for not comply with these conditions.

1. SAMPLE Designation>

Additional Holder 1

Additional Holder 2

Additional Holder 3

Additional Holder 4

183535_223655_MAIL/000001/000001/SG625/i1

Poll Card To be completed only at the AGM if a Poll is called.

Signature

In the case of a Corporation, a letter of representation will be required (in accordance with S323 of the Companies Act 2006) unless this has already been lodged at registration.

Vote

Ordinary Resolutions	For Against Withheld

1. To receive and adopt the Company's annual accounts for the financial year ended 31 December 2022 together with the directors' reports and auditor's report on those accounts (the "2022 Annual Report and Accounts").
2. To approve the Directors' Remuneration Report (other than the Remuneration Policy) as set out in the 2022 Annual Report and Accounts for the financial year ended 31 December 2022.

3. To re-appoint Peter Redmond as a director of the Company.

4. To re-appoint Alexis Sandler as a director of the Company.

appoint Dr Vladislav Sandler as a director of the Company.

appoint PKF Littlejohn LLP as the Company's auditor until the conclusion of the next annual general of the Company.

the Audit committee to determine the level of the auditor's reumeration.

directors be generally and unconditionally authorised to exercise all the powers to allot shares.

directors may allot equity securities (as defined in section 560 of the Companies Act 2006) for the authority conferred by Resolution 8.

10. That a general meeting other than an Annual General Meeting may be called on not less than 14 clear days' notice during the period from the date of the passing of this resolution 10 until the conclusion of the next Annual General Meeting of the Company.

Form of Proxy

Please complete this box only if you wish to appoint a third party proxy other than the Chairman. Please leave this box blank if you want to select the Chairman. Do not insert your own name(s).

*



C0000000000

I/We hereby appoint the Chairman of the Meeting OR the person indicated in the box above as my/our proxy to attend, speak and vote in respect of my/our full voting entitlement* on my/our behalf at the Annual General Meeting of Hemogenyx Pharmaceuticals plc to be held at the offices of Peterhouse Capital Limited, 80 Cheapside, London EC2V 6DZ on 30 June 2023 at 2.00 pm BST, and at any adjourned meeting.

* For the appointment of more than one proxy, please refer to Explanatory Note 2 (see front).

Please use a black pen. Mark with an X

Please mark here to indicate that this proxy appointment is one of multiple appointments being made.

inside the box as shown in this example.

Vote

Vote

Ordinary Resolutions

For

Against Withheld

For

Against Withheld

1.

To receive and adopt the Company's annual accounts for the

7.

To authorise the Audit committee to determine the level of the

financial year ended 31 December 2022 together with the directors'

auditor's reumeration.

reports and auditor's report on those accounts (the "2022 Annual

Report and Accounts").

2.

To approve the Directors' Remuneration Report (other than the

8.

That the directors be generally and unconditionally authorised to

Remuneration Policy) as set out in the 2022 Annual Report and

exercise all the powers to allot shares.

Accounts for the financial year ended 31 December 2022.

Special Resolutions

3.

To re-appoint Peter Redmond as a director of the Company.

9.

That the directors may allot equity securities (as defined in section

560 of the Companies Act 2006) for cash under the authority

conferred by Resolution 8.

4.

To re-appoint Alexis Sandler as a director of the Company.

10.

That a general meeting other than an Annual General Meeting may

be called on not less than 14 clear days' notice during the period

from the date of the passing of this resolution 10 until the conclusion

of the next Annual General Meeting of the Company.

Intention To Attend

5.

To re-appoint Dr Vladislav Sandler as a director of the Company.

Please indicate if you intend to attend the AGM

6. To re-appoint PKF Littlejohn LLP as the Company's auditor until the conclusion of the next annual general meeting of the Company.

I/We instruct my/our proxy as indicated on this form. Unless	he or she sees fit or abstain in relation to any business of the meeting.
Signature	In the case of a corporation, this proxy must be given under its
		common seal or be signed on its behalf by an attorney or officer duly
		authorised, stating their capacity (e.g. director, secretary).

H 6 7 8

1 1

S V E